2mcm

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[[Image:2mcm.jpg|left|200px]]<br /><applet load="2mcm" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2mcm.jpg|left|200px]]
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caption="2mcm, resolution 1.5&Aring;" />
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'''MACROMOMYCIN'''<br />
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{{Structure
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|PDB= 2mcm |SIZE=350|CAPTION= <scene name='initialview01'>2mcm</scene>, resolution 1.5&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene> and <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''MACROMOMYCIN'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2MCM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_macromomyceticus Streptomyces macromomyceticus] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=MRD:'>MRD</scene> and <scene name='pdbligand=MPD:'>MPD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCM OCA].
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2MCM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_macromomyceticus Streptomyces macromomyceticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCM OCA].
==Reference==
==Reference==
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Crystal structure analysis of auromomycin apoprotein (macromomycin) shows importance of protein side chains to chromophore binding selectivity., Van Roey P, Beerman TA, Proc Natl Acad Sci U S A. 1989 Sep;86(17):6587-91. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2771945 2771945]
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Crystal structure analysis of auromomycin apoprotein (macromomycin) shows importance of protein side chains to chromophore binding selectivity., Van Roey P, Beerman TA, Proc Natl Acad Sci U S A. 1989 Sep;86(17):6587-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2771945 2771945]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Streptomyces macromomyceticus]]
[[Category: Streptomyces macromomyceticus]]
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[[Category: apoprotein]]
[[Category: apoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:07:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:46:59 2008''

Revision as of 15:47, 20 March 2008

Image:2mcm.jpg


PDB ID 2mcm

Drag the structure with the mouse to rotate
, resolution 1.5Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



MACROMOMYCIN


Overview

The crystal structure of macromomycin, the apoprotein of the antitumor antibiotic auromomycin, has been determined and refined at 1.6-A resolution. The overall structure is composed of a flattened seven-stranded antiparallel beta-barrel and two antiparallel beta-sheet ribbons. The barrel and the ribbons define a deep cleft that is the chromophore binding site. The cleft is very accessible and in this structure is occupied by two 2-methyl-2,4-pentanediol and two water molecules. The overall shape of the binding site is similar to that of the analogue actinoxanthin. Highly specific side chains that are not conserved between different analogues extend into the binding site and may be important to the chromophore binding specificity.

About this Structure

2MCM is a Single protein structure of sequence from Streptomyces macromomyceticus. Full crystallographic information is available from OCA.

Reference

Crystal structure analysis of auromomycin apoprotein (macromomycin) shows importance of protein side chains to chromophore binding selectivity., Van Roey P, Beerman TA, Proc Natl Acad Sci U S A. 1989 Sep;86(17):6587-91. PMID:2771945

Page seeded by OCA on Thu Mar 20 17:46:59 2008

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