2npl
From Proteopedia
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| - | [[Image:2npl.gif|left|200px]] | + | [[Image:2npl.gif|left|200px]] |
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| - | '''NMR Structure of CARD d2 Domain''' | + | {{Structure |
| + | |PDB= 2npl |SIZE=350|CAPTION= <scene name='initialview01'>2npl</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= CXADR, CAR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''NMR Structure of CARD d2 Domain''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2NPL is a [ | + | 2NPL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPL OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure of the coxsackievirus and adenovirus receptor domain 2., Jiang S, Caffrey M, Protein Sci. 2007 Mar;16(3):539-42. PMID:[http:// | + | Solution structure of the coxsackievirus and adenovirus receptor domain 2., Jiang S, Caffrey M, Protein Sci. 2007 Mar;16(3):539-42. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17322536 17322536] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: coxsakievirus and adenovirus receptor]] | [[Category: coxsakievirus and adenovirus receptor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:49:25 2008'' |
Revision as of 15:49, 20 March 2008
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| Gene: | CXADR, CAR (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR Structure of CARD d2 Domain
Contents |
Overview
The coxsackievirus and adenovirus receptor (CAR) mediates entry of coxsackievirus and adenovirus. CAR possesses an extracellular region that is comprised of 2 immunoglobulin domains termed CAR-D1 and CAR-D2. In the present work, the solution structure of CAR-D2, consisting of residues 142-235 of human CAR, has been determined by NMR spectroscopy. CAR-D2 is shown to be a beta-sandwich motif comprised of two beta-sheets, which are stabilized by two disulfide bonds. The first beta-sheet is comprised of beta-strands A, B, and E, and the second beta-sheet is comprised of beta-strands C, F, and G. A relatively hydrophobic helix is found between beta-strands C and E, which replaces beta-strand D of the classical c-type immunoglobulin fold.
Disease
Known diseases associated with this structure: Adrenocortical tumor, somatic OMIM:[188830], Carney complex, type 1 OMIM:[188830], Myxoma, intracardiac OMIM:[188830], Pigmented adrenocortical disease, primary, 1 OMIM:[188830], Spastic paraplegia-7 OMIM:[602783], Thyroid carcinoma, papillary OMIM:[188830]
About this Structure
2NPL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of the coxsackievirus and adenovirus receptor domain 2., Jiang S, Caffrey M, Protein Sci. 2007 Mar;16(3):539-42. PMID:17322536
Page seeded by OCA on Thu Mar 20 17:49:25 2008
