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2vpg
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vpg]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VPG FirstGlance]. <br> | <table><tr><td colspan='2'>[[2vpg]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VPG FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DA2:NG,NG-DIMETHYL-L-ARGININE'>DA2</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr> | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DA2:NG,NG-DIMETHYL-L-ARGININE'>DA2</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vp7|2vp7]], [[2vpb|2vpb]], [[2vpd|2vpd]], [[2vpe|2vpe]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vp7|2vp7]], [[2vpb|2vpb]], [[2vpd|2vpd]], [[2vpe|2vpe]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vpg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vpg RCSB], [http://www.ebi.ac.uk/pdbsum/2vpg PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vpg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vpg RCSB], [http://www.ebi.ac.uk/pdbsum/2vpg PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/BCL9_HUMAN BCL9_HUMAN]] Note=A chromosomal aberration involving BCL9 is found in a patient with precusor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies. | [[http://www.uniprot.org/uniprot/BCL9_HUMAN BCL9_HUMAN]] Note=A chromosomal aberration involving BCL9 is found in a patient with precusor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies. | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bienz, M | + | [[Category: Bienz, M]] |
| - | [[Category: Evans, P | + | [[Category: Evans, P]] |
| - | [[Category: Fiedler, M | + | [[Category: Fiedler, M]] |
| - | [[Category: Mieszczanek, J | + | [[Category: Mieszczanek, J]] |
| - | [[Category: Muller, J | + | [[Category: Muller, J]] |
| - | [[Category: Nekrasov, M | + | [[Category: Nekrasov, M]] |
| - | [[Category: Rybin, V | + | [[Category: Rybin, V]] |
| - | [[Category: Sanchez-Barrena, M J | + | [[Category: Sanchez-Barrena, M J]] |
[[Category: Bcl9 hd1 domain]] | [[Category: Bcl9 hd1 domain]] | ||
[[Category: Gene regulation]] | [[Category: Gene regulation]] | ||
Revision as of 13:41, 19 January 2015
Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex
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Categories: Homo sapiens | Bienz, M | Evans, P | Fiedler, M | Mieszczanek, J | Muller, J | Nekrasov, M | Rybin, V | Sanchez-Barrena, M J | Bcl9 hd1 domain | Gene regulation | Histone h3k4me2 | Hpygo1 phd domain | Metal-binding | Nucleus | Phosphoprotein | Proto-oncogene | Signaling protein | Wnt signaling complex | Wnt signaling pathway | Zinc-finger
