2nqc

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[[Image:2nqc.jpg|left|200px]]<br /><applet load="2nqc" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2nqc.jpg|left|200px]]
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caption="2nqc, resolution 2.050&Aring;" />
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'''Crystal structure of ig-like domain 23 from human filamin C'''<br />
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{{Structure
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|PDB= 2nqc |SIZE=350|CAPTION= <scene name='initialview01'>2nqc</scene>, resolution 2.050&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal structure of ig-like domain 23 from human filamin C'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2NQC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NI:'>NI</scene>, <scene name='pdbligand=IMD:'>IMD</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQC OCA].
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2NQC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQC OCA].
==Reference==
==Reference==
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Crystal structure of human filamin C domain 23 and small angle scattering model for filamin C 23-24 dimer., Sjekloca L, Pudas R, Sjoblom B, Konarev P, Carugo O, Rybin V, Kiema TR, Svergun D, Ylanne J, Djinovic Carugo K, J Mol Biol. 2007 May 11;368(4):1011-23. Epub 2007 Feb 20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17379241 17379241]
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Crystal structure of human filamin C domain 23 and small angle scattering model for filamin C 23-24 dimer., Sjekloca L, Pudas R, Sjoblom B, Konarev P, Carugo O, Rybin V, Kiema TR, Svergun D, Ylanne J, Djinovic Carugo K, J Mol Biol. 2007 May 11;368(4):1011-23. Epub 2007 Feb 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17379241 17379241]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: metal binding]]
[[Category: metal binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:09:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:49:42 2008''

Revision as of 15:49, 20 March 2008

Image:2nqc.jpg


PDB ID 2nqc

Drag the structure with the mouse to rotate
, resolution 2.050Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



Crystal structure of ig-like domain 23 from human filamin C


Overview

Filamin C is a dimeric, actin-binding protein involved in organization of cortical cytoskeleton and of the sarcomere. We performed crystallographic, small-angle X-ray scattering and analytical ultracentrifugation experiments on the constructs containing carboxy-terminal domains of the protein (domains 23-24 and 19-21). The crystal structure of domain 23 of filamin C showed that the protein adopts the expected immunoglobulin (Ig)-like fold. Small-angle X-ray scattering experiments performed on filamin C tandem Ig-like domains 23 and 24 reveal a dimer that is formed by domain 24 and that domain 23 has little interactions with itself or with domain 24, while the analytical ultracentrifugation experiments showed that the filamin C domains 19-21 form elongated monomers in diluted solutions.

About this Structure

2NQC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human filamin C domain 23 and small angle scattering model for filamin C 23-24 dimer., Sjekloca L, Pudas R, Sjoblom B, Konarev P, Carugo O, Rybin V, Kiema TR, Svergun D, Ylanne J, Djinovic Carugo K, J Mol Biol. 2007 May 11;368(4):1011-23. Epub 2007 Feb 20. PMID:17379241

Page seeded by OCA on Thu Mar 20 17:49:42 2008

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