2kpw
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2kpw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KPW FirstGlance]. <br> | <table><tr><td colspan='2'>[[2kpw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KPW FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LMN2, LMNB, LMNB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LMN2, LMNB, LMNB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kpw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kpw RCSB], [http://www.ebi.ac.uk/pdbsum/2kpw PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kpw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kpw RCSB], [http://www.ebi.ac.uk/pdbsum/2kpw PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/LMNB1_HUMAN LMNB1_HUMAN]] Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:[http://omim.org/entry/169500 169500]]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.<ref>PMID:16951681</ref> | [[http://www.uniprot.org/uniprot/LMNB1_HUMAN LMNB1_HUMAN]] Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:[http://omim.org/entry/169500 169500]]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.<ref>PMID:16951681</ref> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Acton, T | + | [[Category: Acton, T]] |
| - | [[Category: Belote, R | + | [[Category: Belote, R]] |
| - | [[Category: Ciccosanti, C L | + | [[Category: Ciccosanti, C L]] |
| - | [[Category: Everett, J | + | [[Category: Everett, J]] |
| - | [[Category: Hamilton, K | + | [[Category: Hamilton, K]] |
| - | [[Category: Huang, Y | + | [[Category: Huang, Y]] |
| - | [[Category: Montelione, G T | + | [[Category: Montelione, G T]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Swapna, G V.T | + | [[Category: Swapna, G V.T]] |
| - | [[Category: Xiao, R | + | [[Category: Xiao, R]] |
[[Category: Gft]] | [[Category: Gft]] | ||
[[Category: Hr5546a]] | [[Category: Hr5546a]] | ||
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[[Category: Membrane]] | [[Category: Membrane]] | ||
[[Category: Nesg]] | [[Category: Nesg]] | ||
| - | [[Category: Northeast structural genomics consortium]] | ||
[[Category: Nucleus]] | [[Category: Nucleus]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
[[Category: Prenylation]] | [[Category: Prenylation]] | ||
| - | [[Category: Protein structure initiative | + | [[Category: PSI, Protein structure initiative]] |
| - | + | ||
| - | + | ||
[[Category: Structural protein]] | [[Category: Structural protein]] | ||
Revision as of 14:50, 19 January 2015
NMR solution structure of Lamin-B1 protein from Homo sapiens: Northeast Structural Genomics Consortium MEGA target, HR5546A (439-549)
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Categories: Homo sapiens | Acton, T | Belote, R | Ciccosanti, C L | Everett, J | Hamilton, K | Huang, Y | Montelione, G T | Structural genomic | Swapna, G V.T | Xiao, R | Gft | Hr5546a | Intermediate filament | Lamin-b1 | Leukodystrophy | Lipoprotein | Membrane | Nesg | Nucleus | Phosphoprotein | Prenylation | PSI, Protein structure initiative | Structural protein
