2w3l
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2w3l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W3L FirstGlance]. <br> | <table><tr><td colspan='2'>[[2w3l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W3L FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DRO:1-(2-{[(3S)-3-(AMINOMETHYL)-3,4-DIHYDROISOQUINOLIN-2(1H)-YL]CARBONYL}PHENYL)-4-CHLORO-5-METHYL-N,N-DIPHENYL-1H-PYRAZOLE-3-CARBOXAMIDE'>DRO</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DRO:1-(2-{[(3S)-3-(AMINOMETHYL)-3,4-DIHYDROISOQUINOLIN-2(1H)-YL]CARBONYL}PHENYL)-4-CHLORO-5-METHYL-N,N-DIPHENYL-1H-PYRAZOLE-3-CARBOXAMIDE'>DRO</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ysw|1ysw]], [[1g5m|1g5m]], [[1gjh|1gjh]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ysw|1ysw]], [[1g5m|1g5m]], [[1gjh|1gjh]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w3l RCSB], [http://www.ebi.ac.uk/pdbsum/2w3l PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w3l RCSB], [http://www.ebi.ac.uk/pdbsum/2w3l PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. | [[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Candole, B De | + | [[Category: Candole, B De]] |
| - | [[Category: Davis, J | + | [[Category: Davis, J]] |
| - | [[Category: Edwards, C | + | [[Category: Edwards, C]] |
| - | [[Category: Fisher, M | + | [[Category: Fisher, M]] |
| - | [[Category: Ford, D | + | [[Category: Ford, D]] |
| - | [[Category: Hutchinson, B | + | [[Category: Hutchinson, B]] |
| - | [[Category: Lamers, M | + | [[Category: Lamers, M]] |
| - | [[Category: Payne, A | + | [[Category: Payne, A]] |
| - | [[Category: Porter, J | + | [[Category: Porter, J]] |
| - | [[Category: Stubberfield, C | + | [[Category: Stubberfield, C]] |
| - | [[Category: Trevitt, G | + | [[Category: Trevitt, G]] |
| - | [[Category: Turner, J | + | [[Category: Turner, J]] |
| - | [[Category: Watkins, C | + | [[Category: Watkins, C]] |
| - | [[Category: Whitcombe, I | + | [[Category: Whitcombe, I]] |
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
Revision as of 14:58, 19 January 2015
CRYSTAL STRUCTURE OF CHIMAERIC BCL2-XL AND PHENYL TETRAHYDROISOQUINOLINE AMIDE COMPLEX
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Categories: Homo sapiens | Candole, B De | Davis, J | Edwards, C | Fisher, M | Ford, D | Hutchinson, B | Lamers, M | Payne, A | Porter, J | Stubberfield, C | Trevitt, G | Turner, J | Watkins, C | Whitcombe, I | Apoptosis
