2vpd

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vpd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VPD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VPD FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vpd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VPD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VPD FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vp7|2vp7]], [[2vpb|2vpb]], [[2vpe|2vpe]], [[2vpg|2vpg]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vp7|2vp7]], [[2vpb|2vpb]], [[2vpe|2vpe]], [[2vpg|2vpg]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vpd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vpd RCSB], [http://www.ebi.ac.uk/pdbsum/2vpd PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vpd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vpd RCSB], [http://www.ebi.ac.uk/pdbsum/2vpd PDBsum]</span></td></tr>
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<table>
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</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/BCL9_HUMAN BCL9_HUMAN]] Note=A chromosomal aberration involving BCL9 is found in a patient with precusor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies.
[[http://www.uniprot.org/uniprot/BCL9_HUMAN BCL9_HUMAN]] Note=A chromosomal aberration involving BCL9 is found in a patient with precusor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies.
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bienz, M.]]
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[[Category: Bienz, M]]
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[[Category: Evans, P.]]
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[[Category: Evans, P]]
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[[Category: Fiedler, M.]]
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[[Category: Fiedler, M]]
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[[Category: Mieszczanek, J.]]
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[[Category: Mieszczanek, J]]
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[[Category: Muller, J.]]
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[[Category: Muller, J]]
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[[Category: Nekrasov, M.]]
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[[Category: Nekrasov, M]]
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[[Category: Rybin, V.]]
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[[Category: Rybin, V]]
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[[Category: Sanchez-Barrena, M J.]]
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[[Category: Sanchez-Barrena, M J]]
[[Category: Bcl9 hd1 domain]]
[[Category: Bcl9 hd1 domain]]
[[Category: Gene regulation]]
[[Category: Gene regulation]]

Revision as of 15:16, 19 January 2015

DECODING OF METHYLATED HISTONE H3 TAIL BY THE PYGO-BCL9 WNT SIGNALING COMPLEX

2vpd, resolution 2.77Å

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