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2nxp

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[[Image:2nxp.gif|left|200px]]<br /><applet load="2nxp" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2nxp.gif|left|200px]]
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caption="2nxp, resolution 2.17&Aring;" />
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'''Structure of NTD2 domain of the human TAF5 subunit of TFIID'''<br />
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{{Structure
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|PDB= 2nxp |SIZE=350|CAPTION= <scene name='initialview01'>2nxp</scene>, resolution 2.17&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
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|ACTIVITY=
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|GENE= TAF5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Structure of NTD2 domain of the human TAF5 subunit of TFIID'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2NXP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NXP OCA].
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2NXP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NXP OCA].
==Reference==
==Reference==
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Structural analysis and dimerization potential of the human TAF5 subunit of TFIID., Bhattacharya S, Takada S, Jacobson RH, Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1189-94. Epub 2007 Jan 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17227857 17227857]
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Structural analysis and dimerization potential of the human TAF5 subunit of TFIID., Bhattacharya S, Takada S, Jacobson RH, Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1189-94. Epub 2007 Jan 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17227857 17227857]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transcription factor]]
[[Category: transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:12:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:52:29 2008''

Revision as of 15:52, 20 March 2008

Image:2nxp.gif


PDB ID 2nxp

Drag the structure with the mouse to rotate
, resolution 2.17Å
Ligands:
Gene: TAF5 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Structure of NTD2 domain of the human TAF5 subunit of TFIID


Overview

TFIID is an essential factor required for RNA polymerase II transcription but remains poorly understood because of its intrinsic complexity. Human TAF5, a 100-kDa subunit of general transcription factor TFIID, is an essential gene and plays a critical role in assembling the 1.2 MDa TFIID complex. We report here a structural analysis of the TAF5 protein. Our structure at 2.2-A resolution of the TAF5-NTD2 domain reveals an alpha-helical domain with distant structural similarity to RNA polymerase II CTD interacting factors. The TAF5-NTD2 domain contains several conserved clefts likely to be critical for TFIID complex assembly. Our biochemical analysis of the human TAF5 protein demonstrates the ability of the N-terminal half of the TAF5 gene to form a flexible, extended dimer, a key property required for the assembly of the TFIID complex.

About this Structure

2NXP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural analysis and dimerization potential of the human TAF5 subunit of TFIID., Bhattacharya S, Takada S, Jacobson RH, Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1189-94. Epub 2007 Jan 16. PMID:17227857

Page seeded by OCA on Thu Mar 20 17:52:29 2008

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