2mn3
From Proteopedia
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| - | ''' | + | ==Structure of Platypus 'Intermediate' Defensin-like Peptide (Int-DLP)== |
| + | <StructureSection load='2mn3' size='340' side='right' caption='[[2mn3]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2mn3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MN3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MN3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1b8w|1b8w]], [[1zue|1zue]], [[1bnb|1bnb]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mn3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mn3 RCSB], [http://www.ebi.ac.uk/pdbsum/2mn3 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DEFBL_ORNAN DEFBL_ORNAN]] Has antimicrobial activity. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The three-dimensional structure of a chemically synthesized peptide that we have called 'intermediate' defensin-like peptide (Int-DLP), from the platypus genome, was determined by nuclear magnetic resonance (NMR) spectroscopy; and its antimicrobial activity was investigated. The overall structural fold of Int-DLP was similar to that of the DLPs and beta-defensins, however the presence of a third antiparallel beta-strand makes its structure more similar to the beta-defensins than the DLPs. Int-DLP displayed potent antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa. The four arginine residues at the N-terminus of Int-DLP did not affect the overall fold, but were important for its antimicrobial potency. | ||
| - | + | Structure and antimicrobial activity of platypus 'intermediate' defensin-like peptide.,Torres AM, Bansal P, Koh JM, Pages G, Wu MJ, Kuchel PW FEBS Lett. 2014 May 2;588(9):1821-6. doi: 10.1016/j.febslet.2014.03.044. Epub, 2014 Mar 30. PMID:24694388<ref>PMID:24694388</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bansal, P S]] | ||
| + | [[Category: Koh, J M.S]] | ||
| + | [[Category: Kuchel, P W]] | ||
| + | [[Category: Pages, G]] | ||
| + | [[Category: Torres, A M]] | ||
| + | [[Category: Wu, M J]] | ||
| + | [[Category: Antimicrobial protein]] | ||
| + | [[Category: Beta-defensin]] | ||
| + | [[Category: Defensin-like peptide]] | ||
| + | [[Category: Intermediate-dlp]] | ||
| + | [[Category: Platypus defensin]] | ||
Revision as of 16:10, 19 January 2015
Structure of Platypus 'Intermediate' Defensin-like Peptide (Int-DLP)
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