2j8l
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2j8l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J8L FirstGlance]. <br> | <table><tr><td colspan='2'>[[2j8l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J8L FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xx9|1xx9]], [[1xxd|1xxd]], [[1xxf|1xxf]], [[1zhm|1zhm]], [[1zhp|1zhp]], [[1zhr|1zhr]], [[1zjd|1zjd]], [[1zlr|1zlr]], [[1zmj|1zmj]], [[1zml|1zml]], [[1zmn|1zmn]], [[1zom|1zom]], [[1zpz|1zpz]], [[1zrk|1zrk]], [[1zsj|1zsj]], [[1zsk|1zsk]], [[1zsl|1zsl]], [[1ztj|1ztj]], [[1ztk|1ztk]], [[1ztl|1ztl]], [[2j8j|2j8j]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xx9|1xx9]], [[1xxd|1xxd]], [[1xxf|1xxf]], [[1zhm|1zhm]], [[1zhp|1zhp]], [[1zhr|1zhr]], [[1zjd|1zjd]], [[1zlr|1zlr]], [[1zmj|1zmj]], [[1zml|1zml]], [[1zmn|1zmn]], [[1zom|1zom]], [[1zpz|1zpz]], [[1zrk|1zrk]], [[1zsj|1zsj]], [[1zsk|1zsk]], [[1zsl|1zsl]], [[1ztj|1ztj]], [[1ztk|1ztk]], [[1ztl|1ztl]], [[2j8j|2j8j]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j8l RCSB], [http://www.ebi.ac.uk/pdbsum/2j8l PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j8l RCSB], [http://www.ebi.ac.uk/pdbsum/2j8l PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:[http://omim.org/entry/612416 612416]]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.<ref>PMID:2813350</ref> <ref>PMID:1547342</ref> <ref>PMID:7888672</ref> <ref>PMID:7669672</ref> <ref>PMID:9401068</ref> <ref>PMID:9787168</ref> <ref>PMID:10027710</ref> <ref>PMID:10606881</ref> <ref>PMID:11895778</ref> <ref>PMID:15026311</ref> <ref>PMID:15180874</ref> <ref>PMID:15953011</ref> <ref>PMID:16607084</ref> <ref>PMID:18005151</ref> <ref>PMID:21668437</ref> <ref>PMID:21457405</ref> <ref>PMID:22016685</ref> <ref>PMID:22322133</ref> <ref>PMID:21999818</ref> <ref>PMID:22159456</ref> | [[http://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:[http://omim.org/entry/612416 612416]]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.<ref>PMID:2813350</ref> <ref>PMID:1547342</ref> <ref>PMID:7888672</ref> <ref>PMID:7669672</ref> <ref>PMID:9401068</ref> <ref>PMID:9787168</ref> <ref>PMID:10027710</ref> <ref>PMID:10606881</ref> <ref>PMID:11895778</ref> <ref>PMID:15026311</ref> <ref>PMID:15180874</ref> <ref>PMID:15953011</ref> <ref>PMID:16607084</ref> <ref>PMID:18005151</ref> <ref>PMID:21668437</ref> <ref>PMID:21457405</ref> <ref>PMID:22016685</ref> <ref>PMID:22322133</ref> <ref>PMID:21999818</ref> <ref>PMID:22159456</ref> | ||
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[[Category: Coagulation factor XIa]] | [[Category: Coagulation factor XIa]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bu, Z | + | [[Category: Bu, Z]] |
| - | [[Category: Canutescu, A A | + | [[Category: Canutescu, A A]] |
| - | [[Category: Cheng, H | + | [[Category: Cheng, H]] |
| - | [[Category: Riley, P W | + | [[Category: Riley, P W]] |
| - | [[Category: Roder, H | + | [[Category: Roder, H]] |
| - | [[Category: Samuel, D | + | [[Category: Samuel, D]] |
| - | [[Category: Walsh, P N | + | [[Category: Walsh, P N]] |
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
[[Category: Fxi / blood coagulation / pan domain /apple domain / blood coagulation]] | [[Category: Fxi / blood coagulation / pan domain /apple domain / blood coagulation]] | ||
Revision as of 16:18, 19 January 2015
FXI APPLE 4 DOMAIN LOOP-OUT CONFORMATION
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Categories: Coagulation factor XIa | Homo sapiens | Bu, Z | Canutescu, A A | Cheng, H | Riley, P W | Roder, H | Samuel, D | Walsh, P N | Disease mutation | Fxi / blood coagulation / pan domain /apple domain / blood coagulation | Glycoprotein | Heparin-binding | Hydrolase | Protease | Serine protease
