2va6

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2va6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VA6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VA6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2va6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VA6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VA6 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H24:(6S)-2-AMINO-6-(3-METHOXYBIPHENYL-3-YL)-3,6-DIMETHYL-5,6-DIHYDROPYRIMIDIN-4(3H)-ONE'>H24</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H24:(6S)-2-AMINO-6-(3-METHOXYBIPHENYL-3-YL)-3,6-DIMETHYL-5,6-DIHYDROPYRIMIDIN-4(3H)-ONE'>H24</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1m4h|1m4h]], [[1sgz|1sgz]], [[1w50|1w50]], [[1w51|1w51]], [[1xs7|1xs7]], [[1ym4|1ym4]], [[1fkn|1fkn]], [[1py1|1py1]], [[1tqf|1tqf]], [[1ujj|1ujj]], [[1ujk|1ujk]], [[1xn2|1xn2]], [[1xn3|1xn3]], [[1ym2|1ym2]], [[2b8l|2b8l]], [[2b8v|2b8v]], [[2va5|2va5]], [[2va7|2va7]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1m4h|1m4h]], [[1sgz|1sgz]], [[1w50|1w50]], [[1w51|1w51]], [[1xs7|1xs7]], [[1ym4|1ym4]], [[1fkn|1fkn]], [[1py1|1py1]], [[1tqf|1tqf]], [[1ujj|1ujj]], [[1ujk|1ujk]], [[1xn2|1xn2]], [[1xn3|1xn3]], [[1ym2|1ym2]], [[2b8l|2b8l]], [[2b8v|2b8v]], [[2va5|2va5]], [[2va7|2va7]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2va6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2va6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2va6 RCSB], [http://www.ebi.ac.uk/pdbsum/2va6 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2va6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2va6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2va6 RCSB], [http://www.ebi.ac.uk/pdbsum/2va6 PDBsum]</span></td></tr>
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<table>
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</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Memapsin 2]]
[[Category: Memapsin 2]]
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[[Category: Aharony, D.]]
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[[Category: Aharony, D]]
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[[Category: Albert, J S.]]
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[[Category: Albert, J S]]
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[[Category: Andisik, D.]]
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[[Category: Andisik, D]]
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[[Category: Callaghan, O.]]
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[[Category: Callaghan, O]]
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[[Category: Campbell, J B.]]
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[[Category: Campbell, J B]]
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[[Category: Carr, R A.]]
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[[Category: Carr, R A]]
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[[Category: Chessari, G.]]
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[[Category: Chessari, G]]
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[[Category: Congreve, M.]]
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[[Category: Congreve, M]]
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[[Category: Edwards, P D.]]
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[[Category: Edwards, P D]]
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[[Category: Folmer, R H.A.]]
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[[Category: Folmer, R H.A]]
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[[Category: Frederickson, M.]]
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[[Category: Frederickson, M]]
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[[Category: Geschwindner, S.]]
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[[Category: Geschwindner, S]]
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[[Category: Koether, G.]]
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[[Category: Koether, G]]
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[[Category: Kolmodin, K.]]
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[[Category: Kolmodin, K]]
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[[Category: Krumrine, J.]]
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[[Category: Krumrine, J]]
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[[Category: Mauger, R C.]]
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[[Category: Mauger, R C]]
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[[Category: Murray, C W.]]
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[[Category: Murray, C W]]
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[[Category: Olsson, L L.]]
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[[Category: Olsson, L L]]
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[[Category: Patel, S.]]
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[[Category: Patel, S]]
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[[Category: Spear, N.]]
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[[Category: Spear, N]]
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[[Category: Sylvester, M.]]
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[[Category: Sylvester, M]]
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[[Category: Tian, G.]]
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[[Category: Tian, G]]
[[Category: Alzheimer's disease]]
[[Category: Alzheimer's disease]]
[[Category: Aspartic protease]]
[[Category: Aspartic protease]]
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[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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[[Category: Memapsin 2]]
 
[[Category: Membrane]]
[[Category: Membrane]]
[[Category: Protease]]
[[Category: Protease]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Zymogen]]
[[Category: Zymogen]]

Revision as of 16:58, 19 January 2015

X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 24

2va6, resolution 2.50Å

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