2o4v

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[[Image:2o4v.gif|left|200px]]<br /><applet load="2o4v" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2o4v.gif|left|200px]]
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caption="2o4v, resolution 1.94&Aring;" />
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'''An arginine ladder in OprP mediates phosphate specific transfer across the outer membrane'''<br />
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{{Structure
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|PDB= 2o4v |SIZE=350|CAPTION= <scene name='initialview01'>2o4v</scene>, resolution 1.94&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''An arginine ladder in OprP mediates phosphate specific transfer across the outer membrane'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2O4V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=C8E:'>C8E</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O4V OCA].
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2O4V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O4V OCA].
==Reference==
==Reference==
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An arginine ladder in OprP mediates phosphate-specific transfer across the outer membrane., Moraes TF, Bains M, Hancock RE, Strynadka NC, Nat Struct Mol Biol. 2007 Jan;14(1):85-7. Epub 2006 Dec 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17187075 17187075]
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An arginine ladder in OprP mediates phosphate-specific transfer across the outer membrane., Moraes TF, Bains M, Hancock RE, Strynadka NC, Nat Struct Mol Biol. 2007 Jan;14(1):85-7. Epub 2006 Dec 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17187075 17187075]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transport]]
[[Category: transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:14:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:55:07 2008''

Revision as of 15:55, 20 March 2008

Image:2o4v.gif


PDB ID 2o4v

Drag the structure with the mouse to rotate
, resolution 1.94Å
Ligands: , , , and
Coordinates: save as pdb, mmCIF, xml



An arginine ladder in OprP mediates phosphate specific transfer across the outer membrane


Overview

The outer membrane protein OprP mediates the transport of essential phosphate anions into the pathogenic bacterium Pseudomonas aeruginosa. Here we report the crystallographic structure of trimeric OprP at 1.9-A resolution, revealing an unprecedented 9-residue arginine 'ladder' that spans from the extracellular surface down through a constriction zone where phosphate is coordinated. Lysine residues coat the inner periplasmic surface, creating an 'electropositive sink' that pulls the phosphates through the eyelet and into the cell.

About this Structure

2O4V is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

An arginine ladder in OprP mediates phosphate-specific transfer across the outer membrane., Moraes TF, Bains M, Hancock RE, Strynadka NC, Nat Struct Mol Biol. 2007 Jan;14(1):85-7. Epub 2006 Dec 24. PMID:17187075

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