2wtj

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2wtj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WTJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2wtj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WTJ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=WTJ:2-AMINO-5-(2,3-DIHYDROTHIENO[3,4-B][1,4]DIOXIN-5-YL)-N-[2-(DIMETHYLAMINO)ETHYL]PYRIDINE-3-CARBOXAMIDE'>WTJ</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=WTJ:2-AMINO-5-(2,3-DIHYDROTHIENO[3,4-B][1,4]DIOXIN-5-YL)-N-[2-(DIMETHYLAMINO)ETHYL]PYRIDINE-3-CARBOXAMIDE'>WTJ</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wti|2wti]], [[2wtc|2wtc]], [[2wtd|2wtd]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wti|2wti]], [[2wtc|2wtc]], [[2wtd|2wtd]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wtj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wtj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wtj RCSB], [http://www.ebi.ac.uk/pdbsum/2wtj PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wtj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wtj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wtj RCSB], [http://www.ebi.ac.uk/pdbsum/2wtj PDBsum]</span></td></tr>
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<table>
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</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Aherne, G W.]]
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[[Category: Aherne, G W]]
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[[Category: Allen, C E.]]
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[[Category: Allen, C E]]
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[[Category: Anderson, V E.]]
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[[Category: Anderson, V E]]
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[[Category: Antoni, L.]]
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[[Category: Antoni, L]]
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[[Category: Boxall, K.]]
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[[Category: Boxall, K]]
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[[Category: Burns, S.]]
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[[Category: Burns, S]]
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[[Category: Caldwell, J J.]]
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[[Category: Caldwell, J J]]
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[[Category: Collins, I.]]
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[[Category: Collins, I]]
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[[Category: Garrett, M D.]]
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[[Category: Garrett, M D]]
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[[Category: Hilton, S.]]
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[[Category: Hilton, S]]
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[[Category: Naud, S.]]
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[[Category: Naud, S]]
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[[Category: Oliver, A W.]]
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[[Category: Oliver, A W]]
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[[Category: Pearl, L H.]]
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[[Category: Pearl, L H]]
[[Category: Cell cycle]]
[[Category: Cell cycle]]
[[Category: Kinase]]
[[Category: Kinase]]
[[Category: Li-fraumeni syndrome]]
[[Category: Li-fraumeni syndrome]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 08:00, 20 January 2015

CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR

2wtj, resolution 2.10Å

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