2oiu

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[[Image:2oiu.gif|left|200px]]<br /><applet load="2oiu" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2oiu.gif|left|200px]]
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caption="2oiu, resolution 2.60&Aring;" />
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'''L1 Ribozyme Ligase circular adduct'''<br />
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{{Structure
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|PDB= 2oiu |SIZE=350|CAPTION= <scene name='initialview01'>2oiu</scene>, resolution 2.60&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''L1 Ribozyme Ligase circular adduct'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2OIU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIU OCA].
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2OIU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIU OCA].
==Reference==
==Reference==
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The structural basis of ribozyme-catalyzed RNA assembly., Robertson MP, Scott WG, Science. 2007 Mar 16;315(5818):1549-53. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17363667 17363667]
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The structural basis of ribozyme-catalyzed RNA assembly., Robertson MP, Scott WG, Science. 2007 Mar 16;315(5818):1549-53. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17363667 17363667]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Robertson, M P]]
[[Category: Robertson, M P]]
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[[Category: rna]]
[[Category: rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:19:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:00:15 2008''

Revision as of 16:00, 20 March 2008

Image:2oiu.gif


PDB ID 2oiu

Drag the structure with the mouse to rotate
, resolution 2.60Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



L1 Ribozyme Ligase circular adduct


Overview

Life originated, according to the RNA World hypothesis, from self-replicating ribozymes that catalyzed ligation of RNA fragments. We have solved the 2.6 angstrom crystal structure of a ligase ribozyme that catalyzes regiospecific formation of a 5' to 3' phosphodiester bond between the 5'-triphosphate and the 3'-hydroxyl termini of two RNA fragments. Invariant residues form tertiary contacts that stabilize a flexible stem of the ribozyme at the ligation site, where an essential magnesium ion coordinates three phosphates. The structure of the active site permits us to suggest how transition-state stabilization and a general base may catalyze the ligation reaction required for prebiotic RNA assembly.

About this Structure

2OIU is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

The structural basis of ribozyme-catalyzed RNA assembly., Robertson MP, Scott WG, Science. 2007 Mar 16;315(5818):1549-53. PMID:17363667

Page seeded by OCA on Thu Mar 20 18:00:15 2008

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