2okl
From Proteopedia
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| - | [[Image:2okl.jpg|left|200px]] | + | [[Image:2okl.jpg|left|200px]] |
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| - | '''Crystal structure of Peptide Deformylase 2 with actinonin from Bacillus cereus''' | + | {{Structure |
| + | |PDB= 2okl |SIZE=350|CAPTION= <scene name='initialview01'>2okl</scene>, resolution 1.70Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=BB2:ACTINONIN'>BB2</scene> and <scene name='pdbligand=CIT:CITRIC ACID'>CIT</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] | ||
| + | |GENE= def2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1396 Bacillus cereus]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of Peptide Deformylase 2 with actinonin from Bacillus cereus''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2OKL is a [ | + | 2OKL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKL OCA]. |
==Reference== | ==Reference== | ||
| - | Characterization of peptide deformylase2 from B. cereus., Park JK, Kim KH, Moon JH, Kim EE, J Biochem Mol Biol. 2007 Nov 30;40(6):1050-7. PMID:[http:// | + | Characterization of peptide deformylase2 from B. cereus., Park JK, Kim KH, Moon JH, Kim EE, J Biochem Mol Biol. 2007 Nov 30;40(6):1050-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18047803 18047803] |
[[Category: Bacillus cereus]] | [[Category: Bacillus cereus]] | ||
[[Category: Peptide deformylase]] | [[Category: Peptide deformylase]] | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:00:59 2008'' |
Revision as of 16:00, 20 March 2008
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| , resolution 1.70Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , and | ||||||
| Gene: | def2 (Bacillus cereus) | ||||||
| Activity: | Peptide deformylase, with EC number 3.5.1.88 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of Peptide Deformylase 2 with actinonin from Bacillus cereus
Overview
Peptide deformylase (PDF) is a metalloenzyme that removes the N-terminal formyl groups from newly synthesized proteins. It is essential for bacterial survival, and is therefore-considered as a potential target for antimicrobial chemotherapy. However, some bacteria including medically relevant pathogens possess two or more def-like genes. Here we have examined two PDFs from Bacillus cereus. The two share only 32% sequence identity and the crystal structures show overall similarity with PDF2 having a longer C-terminus. However, there are differences at the two active sites, and these differences appear to contribute to the activity difference seen between the two. BcPDF2 is found as a dimer in the crystal form with two additional actinonin bound at that interface.
About this Structure
2OKL is a Single protein structure of sequence from Bacillus cereus. Full crystallographic information is available from OCA.
Reference
Characterization of peptide deformylase2 from B. cereus., Park JK, Kim KH, Moon JH, Kim EE, J Biochem Mol Biol. 2007 Nov 30;40(6):1050-7. PMID:18047803
Page seeded by OCA on Thu Mar 20 18:00:59 2008
Categories: Bacillus cereus | Peptide deformylase | Single protein | Kim, E E. | BB2 | CIT | ZN | Hydrolase
