A Disintegrin And Metalloproteinase
From Proteopedia
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**[[3hy7]], [[3hyg]] – hADAM5 catalytic domain (mutant) - human<br /> | **[[3hy7]], [[3hyg]] – hADAM5 catalytic domain (mutant) - human<br /> | ||
| + | |||
| + | *ADAM8 | ||
| + | |||
| + | **[[4dd8]] – hADAM8 + batimastat<br /> | ||
*ADAM10 | *ADAM10 | ||
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**[[3b2z]] - hADAMTS4 residues 213-520<br /> | **[[3b2z]] - hADAMTS4 residues 213-520<br /> | ||
| + | **[[4wk7]], [[4wke]], [[4wki]] - hADAMTS4 residues 213-439 +inhibitor<br /> | ||
**[[2rjp]] - hADAMTS4 residues 213-520 (mutant) + inhibitor | **[[2rjp]] - hADAMTS4 residues 213-520 (mutant) + inhibitor | ||
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**[[2rjq]] - hADAMTS5 residues 262-628 + inhibitor<br /> | **[[2rjq]] - hADAMTS5 residues 262-628 + inhibitor<br /> | ||
| - | **[[3b8z]], [[3hy7]], [[ | + | **[[3b8z]], [[3hy7]], [[3hy9]], [[3ljt]], [[3hy9]] - hADAMTS5 catalytic domain (mutant) + inhibitor |
*ADAMTS13 | *ADAMTS13 | ||
Revision as of 10:04, 20 January 2015
A Disintegrin And Metalloproteinase (ADAM) are peptidases which cleave off extracellular portions of transmembrane proteins. ADAM inhibitors are used in anti-cancer therapy. ADAM family members are numbered. ADAM10 cleaves ephrin. ADAM13 details in Molecular Playground/ADAM13. ADAM17 (TACE) processes the tumor necrosis factor-α. ADAM33 is implicated in asthma. ADAMTS is ADAM with thrombospondin motifs. ADAMTS1 has anti-angionenic activity. ADAMTS4 and ADAMTS5 are involved in the degradation of aggrecan. ADAMTS13 cleaves von Willebrand factor involved in blood clotting. The images at the left and at the right correspond to one representative ADAM, i.e. the crystal structure of bovine A Disintegrin And Metalloproteinase 10 (2ao7).
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3D Structures of A Disintegrin And Metalloproteinase
Updated on 20-January-2015
