2xhi
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2xhi]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XHI FirstGlance]. <br> | <table><tr><td colspan='2'>[[2xhi]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XHI FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=8OG:8-OXO-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>8OG</scene></td></tr> | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=8OG:8-OXO-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>8OG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2nof|2nof]], [[2noe|2noe]], [[2i5w|2i5w]], [[1lwv|1lwv]], [[1n39|1n39]], [[1fn7|1fn7]], [[2nol|2nol]], [[2noh|2noh]], [[1ko9|1ko9]], [[2nob|2nob]], [[1m3h|1m3h]], [[1hu0|1hu0]], [[1ebm|1ebm]], [[1n3a|1n3a]], [[1m3q|1m3q]], [[1lww|1lww]], [[1lwy|1lwy]], [[2noi|2noi]], [[2noz|2noz]], [[1n3c|1n3c]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2nof|2nof]], [[2noe|2noe]], [[2i5w|2i5w]], [[1lwv|1lwv]], [[1n39|1n39]], [[1fn7|1fn7]], [[2nol|2nol]], [[2noh|2noh]], [[1ko9|1ko9]], [[2nob|2nob]], [[1m3h|1m3h]], [[1hu0|1hu0]], [[1ebm|1ebm]], [[1n3a|1n3a]], [[1m3q|1m3q]], [[1lww|1lww]], [[1lwy|1lwy]], [[2noi|2noi]], [[2noz|2noz]], [[1n3c|1n3c]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xhi RCSB], [http://www.ebi.ac.uk/pdbsum/2xhi PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xhi RCSB], [http://www.ebi.ac.uk/pdbsum/2xhi PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN]] Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:[http://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. | [[http://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN]] Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:[http://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| - | [[Category: Alseth, I | + | [[Category: Alseth, I]] |
| - | [[Category: Backe, P H | + | [[Category: Backe, P H]] |
| - | [[Category: Bjoras, M | + | [[Category: Bjoras, M]] |
| - | [[Category: Dalhus, B | + | [[Category: Dalhus, B]] |
| - | [[Category: Forsbring, M | + | [[Category: Forsbring, M]] |
| - | [[Category: Forstrom, R J | + | [[Category: Forstrom, R J]] |
| - | [[Category: Helle, I H | + | [[Category: Helle, I H]] |
[[Category: Dna repair]] | [[Category: Dna repair]] | ||
[[Category: Helix-hairpin-helix]] | [[Category: Helix-hairpin-helix]] | ||
[[Category: Lyase-dna complex]] | [[Category: Lyase-dna complex]] | ||
[[Category: Separation-of-function mutant]] | [[Category: Separation-of-function mutant]] | ||
Revision as of 10:30, 20 January 2015
Separation-of-function mutants unravel the dual reaction mode of human 8-oxoguanine DNA glycosylase
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