2onj

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[[Image:2onj.gif|left|200px]]<br /><applet load="2onj" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2onj.gif|left|200px]]
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caption="2onj, resolution 3.400&Aring;" />
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'''Structure of the multidrug ABC transporter Sav1866 from S. aureus in complex with AMP-PNP'''<br />
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{{Structure
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|PDB= 2onj |SIZE=350|CAPTION= <scene name='initialview01'>2onj</scene>, resolution 3.400&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> and <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER'>ANP</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Structure of the multidrug ABC transporter Sav1866 from S. aureus in complex with AMP-PNP'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2ONJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] with <scene name='pdbligand=NA:'>NA</scene> and <scene name='pdbligand=ANP:'>ANP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONJ OCA].
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2ONJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONJ OCA].
==Reference==
==Reference==
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Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP., Dawson RJ, Locher KP, FEBS Lett. 2007 Mar 6;581(5):935-8. Epub 2007 Feb 7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17303126 17303126]
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Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP., Dawson RJ, Locher KP, FEBS Lett. 2007 Mar 6;581(5):935-8. Epub 2007 Feb 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17303126 17303126]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: transport protein]]
[[Category: transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:20:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:02:04 2008''

Revision as of 16:02, 20 March 2008

Image:2onj.gif


PDB ID 2onj

Drag the structure with the mouse to rotate
, resolution 3.400Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



Structure of the multidrug ABC transporter Sav1866 from S. aureus in complex with AMP-PNP


Overview

Staphylococcus aureus Sav1866 is a bacterial homolog of the human ABC transporter Mdr1 that causes multidrug resistance in cancer cells. We report the crystal structure of Sav1866 in complex with adenosine-5'-(beta,gamma-imido)triphosphate (AMP-PNP) at 3.4A resolution and compare it with the previously determined structure of Sav1866 with bound ADP. Besides differences in the ATP-binding sites, no significant conformational changes were observed. The results confirm that the ATP-bound state of multidrug ABC transporters is coupled to an outward-facing conformation of the transmembrane domains.

About this Structure

2ONJ is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP., Dawson RJ, Locher KP, FEBS Lett. 2007 Mar 6;581(5):935-8. Epub 2007 Feb 7. PMID:17303126

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