2weo
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2weo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WEO FirstGlance]. <br> | <table><tr><td colspan='2'>[[2weo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WEO FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FBW:3-FLUOROBENZENESULFONAMIDE'>FBW</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FBW:3-FLUOROBENZENESULFONAMIDE'>FBW</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1okl|1okl]], [[1i9q|1i9q]], [[2wej|2wej]], [[1zfq|1zfq]], [[1if7|1if7]], [[1cam|1cam]], [[1t9n|1t9n]], [[1cnw|1cnw]], [[1okn|1okn]], [[1f2w|1f2w]], [[1g52|1g52]], [[2h4n|2h4n]], [[1bnm|1bnm]], [[1cnh|1cnh]], [[1bnq|1bnq]], [[1ugc|1ugc]], [[1xev|1xev]], [[1ugg|1ugg]], [[1if9|1if9]], [[1g53|1g53]], [[1fqm|1fqm]], [[1ca2|1ca2]], [[1cal|1cal]], [[1fql|1fql]], [[1i9n|1i9n]], [[1g4o|1g4o]], [[2cba|2cba]], [[1ydc|1ydc]], [[1ccs|1ccs]], [[1lzv|1lzv]], [[1bnv|1bnv]], [[1fqr|1fqr]], [[1rzb|1rzb]], [[1a42|1a42]], [[1th9|1th9]], [[1zsb|1zsb]], [[1cnb|1cnb]], [[1hed|1hed]], [[1i8z|1i8z]], [[1g48|1g48]], [[1lg5|1lg5]], [[1bv3|1bv3]], [[1g0f|1g0f]], [[1tg3|1tg3]], [[1cvc|1cvc]], [[1ugd|1ugd]], [[1i90|1i90]], [[1yo0|1yo0]], [[2wd3|2wd3]], [[1fsn|1fsn]], [[1hva|1hva]], [[1rze|1rze]], [[1ugb|1ugb]], [[1z9y|1z9y]], [[2weh|2weh]], [[2fmz|2fmz]], [[1cnk|1cnk]], [[1bn1|1bn1]], [[1teq|1teq]], [[1rza|1rza]], [[2vvb|2vvb]], [[1ccu|1ccu]], [[1i9l|1i9l]], [[2cbc|2cbc]], [[1g46|1g46]], [[1cvb|1cvb]], [[1cao|1cao]], [[1fsq|1fsq]], [[6ca2|6ca2]], [[5ca2|5ca2]], [[1g1d|1g1d]], [[1caj|1caj]], [[1cvf|1cvf]], [[2fou|2fou]], [[1lgd|1lgd]], [[1if6|1if6]], [[1bn4|1bn4]], [[1teu|1teu]], [[1cra|1cra]], [[1ze8|1ze8]], [[1if4|1if4]], [[1hea|1hea]], [[1hca|1hca]], [[1cah|1cah]], [[1g4j|1g4j]], [[1raz|1raz]], [[1kwq|1kwq]], [[1cim|1cim]], [[1cvh|1cvh]], [[1if8|1if8]], [[1cin|1cin]], [[1i9m|1i9m]], [[1zfk|1zfk]], [[1fqn|1fqn]], [[1zsa|1zsa]], [[1lg6|1lg6]], [[1cnc|1cnc]], [[1bnn|1bnn]], [[1uga|1uga]], [[2foq|2foq]], [[1tb0|1tb0]], [[1cai|1cai]], [[2ax2|2ax2]], [[1dcb|1dcb]], [[1cnx|1cnx]], [[2hd6|2hd6]], [[5cac|5cac]], [[4cac|4cac]], [[1ttm|1ttm]], [[1cak|1cak]], [[1i9o|1i9o]], [[1cni|1cni]], [[1can|1can]], [[2eu3|2eu3]], [[1yda|1yda]], [[2wd2|2wd2]], [[1yo2|1yo2]], [[1eou|1eou]], [[1mua|1mua]], [[2ca2|2ca2]], [[1cct|1cct]], [[2abe|2abe]], [[1oq5|1oq5]], [[1rzc|1rzc]], [[1ugf|1ugf]], [[2cbe|2cbe]], [[1thk|1thk]], [[1kwr|1kwr]], [[1zgf|1zgf]], [[1cay|1cay]], [[1moo|1moo]], [[1cng|1cng]], [[1hec|1hec]], [[2ez7|2ez7]], [[8ca2|8ca2]], [[9ca2|9ca2]], [[1fr7|1fr7]], [[1zh9|1zh9]], [[1ydd|1ydd]], [[1bic|1bic]], [[1lug|1lug]], [[1caz|1caz]], [[1cvd|1cvd]], [[7ca2|7ca2]], [[1fr4|1fr4]], [[1cil|1cil]], [[4ca2|4ca2]], [[2geh|2geh]], [[1g45|1g45]], [[1ydb|1ydb]], [[1dca|1dca]], [[1fsr|1fsr]], [[2cbb|2cbb]], [[1i9p|1i9p]], [[12ca|12ca]], [[1avn|1avn]], [[1bcd|1bcd]], [[1am6|1am6]], [[1i91|1i91]], [[1cve|1cve]], [[1g3z|1g3z]], [[1heb|1heb]], [[2cbd|2cbd]], [[1zsc|1zsc]], [[2weg|2weg]], [[3ca2|3ca2]], [[1bnu|1bnu]], [[1zge|1zge]], [[1bnw|1bnw]], [[2fov|2fov]], [[1te3|1te3]], [[1bnt|1bnt]], [[1if5|1if5]], [[1yo1|1yo1]], [[1rzd|1rzd]], [[1g54|1g54]], [[1uge|1uge]], [[1g0e|1g0e]], [[2fmg|2fmg]], [[1ray|1ray]], [[1cva|1cva]], [[1ca3|1ca3]], [[2eu2|2eu2]], [[1tg9|1tg9]], [[1tbt|1tbt]], [[1xeg|1xeg]], [[1bn3|1bn3]], [[1okm|1okm]], [[1cny|1cny]], [[1cnj|1cnj]], [[1h9n|1h9n]], [[2vva|2vva]], [[2aw1|2aw1]], [[1h4n|1h4n]], [[2fos|2fos]], [[1h9q|1h9q]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1okl|1okl]], [[1i9q|1i9q]], [[2wej|2wej]], [[1zfq|1zfq]], [[1if7|1if7]], [[1cam|1cam]], [[1t9n|1t9n]], [[1cnw|1cnw]], [[1okn|1okn]], [[1f2w|1f2w]], [[1g52|1g52]], [[2h4n|2h4n]], [[1bnm|1bnm]], [[1cnh|1cnh]], [[1bnq|1bnq]], [[1ugc|1ugc]], [[1xev|1xev]], [[1ugg|1ugg]], [[1if9|1if9]], [[1g53|1g53]], [[1fqm|1fqm]], [[1ca2|1ca2]], [[1cal|1cal]], [[1fql|1fql]], [[1i9n|1i9n]], [[1g4o|1g4o]], [[2cba|2cba]], [[1ydc|1ydc]], [[1ccs|1ccs]], [[1lzv|1lzv]], [[1bnv|1bnv]], [[1fqr|1fqr]], [[1rzb|1rzb]], [[1a42|1a42]], [[1th9|1th9]], [[1zsb|1zsb]], [[1cnb|1cnb]], [[1hed|1hed]], [[1i8z|1i8z]], [[1g48|1g48]], [[1lg5|1lg5]], [[1bv3|1bv3]], [[1g0f|1g0f]], [[1tg3|1tg3]], [[1cvc|1cvc]], [[1ugd|1ugd]], [[1i90|1i90]], [[1yo0|1yo0]], [[2wd3|2wd3]], [[1fsn|1fsn]], [[1hva|1hva]], [[1rze|1rze]], [[1ugb|1ugb]], [[1z9y|1z9y]], [[2weh|2weh]], [[2fmz|2fmz]], [[1cnk|1cnk]], [[1bn1|1bn1]], [[1teq|1teq]], [[1rza|1rza]], [[2vvb|2vvb]], [[1ccu|1ccu]], [[1i9l|1i9l]], [[2cbc|2cbc]], [[1g46|1g46]], [[1cvb|1cvb]], [[1cao|1cao]], [[1fsq|1fsq]], [[6ca2|6ca2]], [[5ca2|5ca2]], [[1g1d|1g1d]], [[1caj|1caj]], [[1cvf|1cvf]], [[2fou|2fou]], [[1lgd|1lgd]], [[1if6|1if6]], [[1bn4|1bn4]], [[1teu|1teu]], [[1cra|1cra]], [[1ze8|1ze8]], [[1if4|1if4]], [[1hea|1hea]], [[1hca|1hca]], [[1cah|1cah]], [[1g4j|1g4j]], [[1raz|1raz]], [[1kwq|1kwq]], [[1cim|1cim]], [[1cvh|1cvh]], [[1if8|1if8]], [[1cin|1cin]], [[1i9m|1i9m]], [[1zfk|1zfk]], [[1fqn|1fqn]], [[1zsa|1zsa]], [[1lg6|1lg6]], [[1cnc|1cnc]], [[1bnn|1bnn]], [[1uga|1uga]], [[2foq|2foq]], [[1tb0|1tb0]], [[1cai|1cai]], [[2ax2|2ax2]], [[1dcb|1dcb]], [[1cnx|1cnx]], [[2hd6|2hd6]], [[5cac|5cac]], [[4cac|4cac]], [[1ttm|1ttm]], [[1cak|1cak]], [[1i9o|1i9o]], [[1cni|1cni]], [[1can|1can]], [[2eu3|2eu3]], [[1yda|1yda]], [[2wd2|2wd2]], [[1yo2|1yo2]], [[1eou|1eou]], [[1mua|1mua]], [[2ca2|2ca2]], [[1cct|1cct]], [[2abe|2abe]], [[1oq5|1oq5]], [[1rzc|1rzc]], [[1ugf|1ugf]], [[2cbe|2cbe]], [[1thk|1thk]], [[1kwr|1kwr]], [[1zgf|1zgf]], [[1cay|1cay]], [[1moo|1moo]], [[1cng|1cng]], [[1hec|1hec]], [[2ez7|2ez7]], [[8ca2|8ca2]], [[9ca2|9ca2]], [[1fr7|1fr7]], [[1zh9|1zh9]], [[1ydd|1ydd]], [[1bic|1bic]], [[1lug|1lug]], [[1caz|1caz]], [[1cvd|1cvd]], [[7ca2|7ca2]], [[1fr4|1fr4]], [[1cil|1cil]], [[4ca2|4ca2]], [[2geh|2geh]], [[1g45|1g45]], [[1ydb|1ydb]], [[1dca|1dca]], [[1fsr|1fsr]], [[2cbb|2cbb]], [[1i9p|1i9p]], [[12ca|12ca]], [[1avn|1avn]], [[1bcd|1bcd]], [[1am6|1am6]], [[1i91|1i91]], [[1cve|1cve]], [[1g3z|1g3z]], [[1heb|1heb]], [[2cbd|2cbd]], [[1zsc|1zsc]], [[2weg|2weg]], [[3ca2|3ca2]], [[1bnu|1bnu]], [[1zge|1zge]], [[1bnw|1bnw]], [[2fov|2fov]], [[1te3|1te3]], [[1bnt|1bnt]], [[1if5|1if5]], [[1yo1|1yo1]], [[1rzd|1rzd]], [[1g54|1g54]], [[1uge|1uge]], [[1g0e|1g0e]], [[2fmg|2fmg]], [[1ray|1ray]], [[1cva|1cva]], [[1ca3|1ca3]], [[2eu2|2eu2]], [[1tg9|1tg9]], [[1tbt|1tbt]], [[1xeg|1xeg]], [[1bn3|1bn3]], [[1okm|1okm]], [[1cny|1cny]], [[1cnj|1cnj]], [[1h9n|1h9n]], [[2vva|2vva]], [[2aw1|2aw1]], [[1h4n|1h4n]], [[2fos|2fos]], [[1h9q|1h9q]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2weo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2weo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2weo RCSB], [http://www.ebi.ac.uk/pdbsum/2weo PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2weo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2weo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2weo RCSB], [http://www.ebi.ac.uk/pdbsum/2weo PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref> | [[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref> | ||
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[[Category: Carbonate dehydratase]] | [[Category: Carbonate dehydratase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Alex, A | + | [[Category: Alex, A]] |
| - | [[Category: Bent, A | + | [[Category: Bent, A]] |
| - | [[Category: Brien, R O | + | [[Category: Brien, R O]] |
| - | [[Category: Damian, L | + | [[Category: Damian, L]] |
| - | [[Category: Jones, L H | + | [[Category: Jones, L H]] |
| - | [[Category: Phillips, C | + | [[Category: Phillips, C]] |
| - | [[Category: Scott, A D | + | [[Category: Scott, A D]] |
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
[[Category: Lyase]] | [[Category: Lyase]] | ||
[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
Revision as of 10:59, 20 January 2015
THERMODYNAMIC OPTIMISATION OF CARBONIC ANHYDRASE FRAGMENT INHIBITORS
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