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4k9g
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4k9g]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K9G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K9G FirstGlance]. <br> | <table><tr><td colspan='2'>[[4k9g]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K9G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K9G FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1Q1:1-[(5S)-3-(3-FLUORO-4-HYDROXYPHENYL)-4,5-DIHYDRO-1,2-OXAZOL-5-YL]PROPAN-2-ONE'>1Q1</scene>, <scene name='pdbligand=1Q2:(4R,6Z)-6-(3-FLUORO-4-HYDROXYPHENYL)-4-HYDROXY-6-IMINOHEXAN-2-ONE'>1Q2</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1Q1:1-[(5S)-3-(3-FLUORO-4-HYDROXYPHENYL)-4,5-DIHYDRO-1,2-OXAZOL-5-YL]PROPAN-2-ONE'>1Q1</scene>, <scene name='pdbligand=1Q2:(4R,6Z)-6-(3-FLUORO-4-HYDROXYPHENYL)-4-HYDROXY-6-IMINOHEXAN-2-ONE'>1Q2</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ljt|1ljt]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ljt|1ljt]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k9g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k9g RCSB], [http://www.ebi.ac.uk/pdbsum/4k9g PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k9g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k9g RCSB], [http://www.ebi.ac.uk/pdbsum/4k9g PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. | [[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Al-Abed, Y | + | [[Category: Al-Abed, Y]] |
| - | [[Category: Crichlow, G V | + | [[Category: Crichlow, G V]] |
| - | [[Category: Lolis, E J | + | [[Category: Lolis, E J]] |
[[Category: Cytokine]] | [[Category: Cytokine]] | ||
[[Category: Isomerase]] | [[Category: Isomerase]] | ||
[[Category: Secreted/endocytosed]] | [[Category: Secreted/endocytosed]] | ||
Revision as of 11:04, 20 January 2015
1.55 A Crystal Structure of Macrophage Migration Inhibitory Factor bound to ISO-66 and a related compound
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