3hdi

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[[Image:3hdi.png|left|200px]]
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==Crystal structure of Bacillus halodurans metallo peptidase==
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<StructureSection load='3hdi' size='340' side='right' caption='[[3hdi]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3hdi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_halodurans_c-125 Bacillus halodurans c-125]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HDI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HDI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BH2405 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272558 Bacillus halodurans C-125])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hdi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hdi RCSB], [http://www.ebi.ac.uk/pdbsum/3hdi PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hd/3hdi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The M16 family of zinc peptidases comprises a pair of homologous domains that form two halves of a "clam-shell" surrounding the active site. The M16A and M16C subfamilies form one class ("peptidasomes"): they degrade 30-70 residue peptides, and adopt both open and closed conformations. The eukaryotic M16B subfamily forms a second class ("processing proteases"): they adopt a single partly-open conformation that enables them to cleave signal sequences from larger proteins. Here, we report the solution and crystal structures of a prokaryotic M16B peptidase, and demonstrate that it has features of both classes: thus, it forms stable "open" homodimers in solution that resemble the processing proteases; but the clam-shell closes upon binding substrate, a feature of the M16A/C peptidasomes. Moreover, clam-shell closure is required for proteolytic activity. We predict that other prokaryotic M16B family members will form dimeric peptidasomes, and propose a model for the evolution of the M16 family.
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{{STRUCTURE_3hdi| PDB=3hdi | SCENE= }}
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Crystal and solution structures of a prokaryotic M16B peptidase: an open and shut case.,Aleshin AE, Gramatikova S, Hura GL, Bobkov A, Strongin AY, Stec B, Tainer JA, Liddington RC, Smith JW Structure. 2009 Nov 11;17(11):1465-75. PMID:19913481<ref>PMID:19913481</ref>
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===Crystal structure of Bacillus halodurans metallo peptidase===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19913481}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3hdi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_halodurans_c-125 Bacillus halodurans c-125]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HDI OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019913481</ref><references group="xtra"/>
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[[Category: Bacillus halodurans c-125]]
[[Category: Bacillus halodurans c-125]]
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[[Category: Aleshin, A.]]
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[[Category: Aleshin, A]]
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[[Category: Gramatikova, S.]]
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[[Category: Gramatikova, S]]
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[[Category: Liddington, R C.]]
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[[Category: Liddington, R C]]
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[[Category: Smith, J W.]]
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[[Category: Smith, J W]]
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[[Category: Stec, B.]]
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[[Category: Stec, B]]
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[[Category: Strongin, A Y.]]
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[[Category: Strongin, A Y]]
[[Category: Cage structure]]
[[Category: Cage structure]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Revision as of 11:48, 20 January 2015

Crystal structure of Bacillus halodurans metallo peptidase

3hdi, resolution 2.70Å

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