2ot8

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[[Image:2ot8.gif|left|200px]]<br /><applet load="2ot8" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2ot8.gif|left|200px]]
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caption="2ot8, resolution 3.1&Aring;" />
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'''Karyopherin Beta2/Transportin-hnRNPM NLS Complex'''<br />
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{{Structure
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|PDB= 2ot8 |SIZE=350|CAPTION= <scene name='initialview01'>2ot8</scene>, resolution 3.1&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= TNPO1, KPNB2, MIP1, TRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), HNRPM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Karyopherin Beta2/Transportin-hnRNPM NLS Complex'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2OT8 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OT8 OCA].
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2OT8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OT8 OCA].
==Reference==
==Reference==
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Structure-based design of a pathway-specific nuclear import inhibitor., Cansizoglu AE, Lee BJ, Zhang ZC, Fontoura BM, Chook YM, Nat Struct Mol Biol. 2007 May;14(5):452-4. Epub 2007 Apr 15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17435768 17435768]
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Structure-based design of a pathway-specific nuclear import inhibitor., Cansizoglu AE, Lee BJ, Zhang ZC, Fontoura BM, Chook YM, Nat Struct Mol Biol. 2007 May;14(5):452-4. Epub 2007 Apr 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17435768 17435768]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: nuclear import complex]]
[[Category: nuclear import complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:22:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:04:10 2008''

Revision as of 16:04, 20 March 2008

Image:2ot8.gif


PDB ID 2ot8

Drag the structure with the mouse to rotate
, resolution 3.1Å
Gene: TNPO1, KPNB2, MIP1, TRN (Homo sapiens), HNRPM (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Karyopherin Beta2/Transportin-hnRNPM NLS Complex


Contents

Overview

Kapbeta2 (also called transportin) recognizes PY nuclear localization signal (NLS), a new class of NLS with a R/H/Kx((2-5))PY motif. Here we show that Kapbeta2 complexes containing hydrophobic and basic PY-NLSs, as classified by the composition of an additional N-terminal motif, converge in structure only at consensus motifs, which explains ligand diversity. On the basis of these data and complementary biochemical analyses, we designed a Kapbeta2-specific nuclear import inhibitor, M9M.

Disease

Known disease associated with this structure: Deafness, mitochondrial, modifier of OMIM:[610230]

About this Structure

2OT8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-based design of a pathway-specific nuclear import inhibitor., Cansizoglu AE, Lee BJ, Zhang ZC, Fontoura BM, Chook YM, Nat Struct Mol Biol. 2007 May;14(5):452-4. Epub 2007 Apr 15. PMID:17435768

Page seeded by OCA on Thu Mar 20 18:04:10 2008

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