2oul
From Proteopedia
(New page: 200px<br /><applet load="2oul" size="350" color="white" frame="true" align="right" spinBox="true" caption="2oul, resolution 2.20Å" /> '''The Structure of Cha...) |
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| - | [[Image:2oul.jpg|left|200px]] | + | [[Image:2oul.jpg|left|200px]] |
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| - | '''The Structure of Chagasin in Complex with a Cysteine Protease Clarifies the Binding Mode and Evolution of a New Inhibitor Family''' | + | {{Structure |
| + | |PDB= 2oul |SIZE=350|CAPTION= <scene name='initialview01'>2oul</scene>, resolution 2.20Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= AAF97809 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum]), cha ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 Trypanosoma cruzi]) | ||
| + | }} | ||
| + | |||
| + | '''The Structure of Chagasin in Complex with a Cysteine Protease Clarifies the Binding Mode and Evolution of a New Inhibitor Family''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2OUL is a [ | + | 2OUL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum] and [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OUL OCA]. |
==Reference== | ==Reference== | ||
| - | The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family., Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH, Structure. 2007 May;15(5):535-43. PMID:[http:// | + | The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family., Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH, Structure. 2007 May;15(5):535-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17502099 17502099] |
[[Category: Plasmodium falciparum]] | [[Category: Plasmodium falciparum]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: macromolecular interaction]] | [[Category: macromolecular interaction]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:04:42 2008'' |
Revision as of 16:04, 20 March 2008
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| , resolution 2.20Å | |||||||
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| Gene: | AAF97809 (Plasmodium falciparum), cha (Trypanosoma cruzi) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
The Structure of Chagasin in Complex with a Cysteine Protease Clarifies the Binding Mode and Evolution of a New Inhibitor Family
Overview
Protein inhibitors of proteolytic enzymes regulate proteolysis and prevent the pathological effects of excess endogenous or exogenous proteases. Cysteine proteases are a large family of enzymes found throughout the plant and animal kingdoms. Disturbance of the equilibrium between cysteine proteases and natural inhibitors is a key event in the pathogenesis of cancer, rheumatoid arthritis, osteoporosis, and emphysema. A family (I42) of cysteine protease inhibitors (http://merops.sanger.ac.uk) was discovered in protozoan parasites and recently found widely distributed in prokaryotes and eukaryotes. We report the 2.2 A crystal structure of the signature member of the I42 family, chagasin, in complex with a cysteine protease. Chagasin has a unique variant of the immunoglobulin fold with homology to human CD8alpha. Interactions of chagasin with a target protease are reminiscent of the cystatin family inhibitors. Protein inhibitors of cysteine proteases may have evolved more than once on nonhomologous scaffolds.
About this Structure
2OUL is a Protein complex structure of sequences from Plasmodium falciparum and Trypanosoma cruzi. Full crystallographic information is available from OCA.
Reference
The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family., Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH, Structure. 2007 May;15(5):535-43. PMID:17502099
Page seeded by OCA on Thu Mar 20 18:04:42 2008
