3wih

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'''Unreleased structure'''
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==Crystal structure of the third fibronectin domain (Fn3) of human ROBO1 in complex with the Fab fragment of murine monoclonal antibody B2212A.==
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<StructureSection load='3wih' size='340' side='right' caption='[[3wih]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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The entry 3wih is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3wih]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WIH FirstGlance]. <br>
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Authors: Nakayama, T., Mizohata, E., Yamashita, T., Nagatoishi, M., Iwanari, H., Mochizuki, Y., Kado, Y., Yokota, Y., Sato, R., Tsumoto, K., Fujitani, H., Kodama, T., Hamakubo, T., Inoue, T.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wii|3wii]]</td></tr>
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Description: Crystal structure of the third fibronectin domain (Fn3) of human ROBO1 in complex with the Fab fragment of murine monoclonal antibody B2212A.
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wih OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wih RCSB], [http://www.ebi.ac.uk/pdbsum/3wih PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Mizohata, E]]
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== Function ==
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[[http://www.uniprot.org/uniprot/ROBO1_HUMAN ROBO1_HUMAN]] Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development.<ref>PMID:10102268</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Mus musculus]]
[[Category: Fujitani, H]]
[[Category: Fujitani, H]]
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[[Category: Tsumoto, K]]
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[[Category: Hamakubo, T]]
[[Category: Inoue, T]]
[[Category: Inoue, T]]
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[[Category: Iwanari, H]]
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[[Category: Kado, Y]]
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[[Category: Kodama, T]]
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[[Category: Mizohata, E]]
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[[Category: Mochizuki, Y]]
[[Category: Nagatoishi, M]]
[[Category: Nagatoishi, M]]
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[[Category: Yokota, Y]]
 
[[Category: Nakayama, T]]
[[Category: Nakayama, T]]
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[[Category: Hamakubo, T]]
 
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[[Category: Mochizuki, Y]]
 
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[[Category: Kodama, T]]
 
[[Category: Sato, R]]
[[Category: Sato, R]]
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[[Category: Iwanari, H]]
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[[Category: Tsumoto, K]]
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[[Category: Kado, Y]]
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[[Category: Yamashita, T]]
[[Category: Yamashita, T]]
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[[Category: Yokota, Y]]
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[[Category: Angiogenesis]]
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[[Category: Fibronectin type-iii domain]]
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[[Category: Hepatocellular carcinoma antigen]]
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[[Category: Immune system]]

Revision as of 16:53, 21 January 2015

Crystal structure of the third fibronectin domain (Fn3) of human ROBO1 in complex with the Fab fragment of murine monoclonal antibody B2212A.

3wih, resolution 1.70Å

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