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4cbg

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'''Unreleased structure'''
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==Pestivirus NS3 helicase==
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<StructureSection load='4cbg' size='340' side='right' caption='[[4cbg]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
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The entry 4cbg is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4cbg]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CBG FirstGlance]. <br>
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Authors: Tortorici, M.A., Duquerroy, S., Kwok, J., Vonrhein, C., Perez, J., Lamp, B., Bricogne, G., Rumenapf, T., Vachette, P., Rey, F.A.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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Description: Pestivirus NS3 helicase
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cbh|4cbh]], [[4cbi|4cbi]], [[4cbl|4cbl]], [[4cbm|4cbm]]</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cbg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cbg RCSB], [http://www.ebi.ac.uk/pdbsum/4cbg PDBsum]</span></td></tr>
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[[Category: Lamp, B]]
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</table>
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[[Category: Vachette, P]]
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== Function ==
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[[Category: Rumenapf, T]]
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[[http://www.uniprot.org/uniprot/POLG_CSFVA POLG_CSFVA]] E(rns), E1 and E2 are responsible of cell attachment and subsequent fusion of viral and cellular membrane. P7 forms a leader sequence to properly orient NS2 in the membrane. Uncleaved NS2-3 is required for production of infectious virus. NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus.[PROSITE-ProRule:PRU01029] NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS4A is a cofactor for the NS3 protease activity. RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.[PROSITE-ProRule:PRU00539]
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__TOC__
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</StructureSection>
[[Category: Bricogne, G]]
[[Category: Bricogne, G]]
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[[Category: Perez, J]]
 
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[[Category: Vonrhein, C]]
 
[[Category: Duquerroy, S]]
[[Category: Duquerroy, S]]
[[Category: Kwok, J]]
[[Category: Kwok, J]]
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[[Category: Tortorici, M.A]]
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[[Category: Lamp, B]]
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[[Category: Rey, F.A]]
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[[Category: Perez, J]]
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[[Category: Rey, F A]]
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[[Category: Rumenapf, T]]
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[[Category: Tortorici, M A]]
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[[Category: Vachette, P]]
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[[Category: Vonrhein, C]]
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[[Category: Flaviviridae ns3]]
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[[Category: Hydrolase]]
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[[Category: Sax]]

Revision as of 16:54, 21 January 2015

Pestivirus NS3 helicase

4cbg, resolution 2.82Å

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