4cl6
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) from Pseudomonas aeruginosa in complex with N-(4- Chlorobenzyl)-3-(2-furyl)-1H-1,2,4-triazol-5-amine== | |
| - | + | <StructureSection load='4cl6' size='340' side='right' caption='[[4cl6]], [[Resolution|resolution]] 2.41Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4cl6]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CL6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7SB:N-(4-CHLOROBENZYL)-5-(FURAN-2-YL)-1H-1,2,4-TRIAZOL-3-AMINE'>7SB</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cl6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cl6 RCSB], [http://www.ebi.ac.uk/pdbsum/4cl6 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/FABA_PSEAE FABA_PSEAE]] Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length (By similarity). |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Duthie, F G]] | ||
| + | [[Category: McMahon, S A]] | ||
[[Category: Moynie, L]] | [[Category: Moynie, L]] | ||
| - | [[Category: | + | [[Category: Naismith, J H]] |
| - | [[Category: | + | [[Category: Bacterial virulence]] |
| + | [[Category: Drug discovery]] | ||
| + | [[Category: Fatty acid biosynthesis]] | ||
| + | [[Category: Lyase]] | ||
Revision as of 16:55, 21 January 2015
Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) from Pseudomonas aeruginosa in complex with N-(4- Chlorobenzyl)-3-(2-furyl)-1H-1,2,4-triazol-5-amine
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