2ox8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2ox8.jpg|left|200px]]<br /><applet load="2ox8" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:2ox8.jpg|left|200px]]
-
caption="2ox8, resolution 2.50&Aring;" />
+
 
-
'''Human Scavenger Receptor C-type Lectin carbohydrate-recognition domain.'''<br />
+
{{Structure
 +
|PDB= 2ox8 |SIZE=350|CAPTION= <scene name='initialview01'>2ox8</scene>, resolution 2.50&Aring;
 +
|SITE=
 +
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
 +
|ACTIVITY=
 +
|GENE= SRCL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
 +
}}
 +
 
 +
'''Human Scavenger Receptor C-type Lectin carbohydrate-recognition domain.'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
2OX8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OX8 OCA].
+
2OX8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OX8 OCA].
==Reference==
==Reference==
-
Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis(x) by a novel mechanism., Feinberg H, Taylor ME, Weis WI, J Biol Chem. 2007 Jun 8;282(23):17250-8. Epub 2007 Apr 9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17420244 17420244]
+
Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis(x) by a novel mechanism., Feinberg H, Taylor ME, Weis WI, J Biol Chem. 2007 Jun 8;282(23):17250-8. Epub 2007 Apr 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17420244 17420244]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 22: Line 31:
[[Category: c-type lectin]]
[[Category: c-type lectin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:23:39 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:05:45 2008''

Revision as of 16:05, 20 March 2008

Image:2ox8.jpg


PDB ID 2ox8

Drag the structure with the mouse to rotate
, resolution 2.50Å
Ligands: , and
Gene: SRCL (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Human Scavenger Receptor C-type Lectin carbohydrate-recognition domain.


Overview

The scavenger receptor C-type lectin (SRCL) is unique in the family of class A scavenger receptors, because in addition to binding sites for oxidized lipoproteins it also contains a C-type carbohydrate-recognition domain (CRD) that interacts with specific glycans. Both human and mouse SRCL are highly specific for the Lewis(x) trisaccharide, which is commonly found on the surfaces of leukocytes and some tumor cells. Structural analysis of the CRD of mouse SRCL in complex with Lewis(x) and mutagenesis show the basis for this specificity. The interaction between mouse SRCL and Lewis(x) is analogous to the way that selectins and DC-SIGN bind to related fucosylated glycans, but the mechanism of the interaction is novel, because it is based on a primary galactose-binding site similar to the binding site in the asialoglycoprotein receptor. Crystals of the human receptor lacking bound calcium ions reveal an alternative conformation in which a glycan ligand would be released during receptor-mediated endocytosis.

About this Structure

2OX8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis(x) by a novel mechanism., Feinberg H, Taylor ME, Weis WI, J Biol Chem. 2007 Jun 8;282(23):17250-8. Epub 2007 Apr 9. PMID:17420244

Page seeded by OCA on Thu Mar 20 18:05:45 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ox8"
Personal tools