2oxh
From Proteopedia
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| - | [[Image:2oxh.jpg|left|200px]] | + | [[Image:2oxh.jpg|left|200px]] |
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| - | '''The SOXYZ Complex of Paracoccus Pantotrophus''' | + | {{Structure |
| + | |PDB= 2oxh |SIZE=350|CAPTION= <scene name='initialview01'>2oxh</scene>, resolution 2.35Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= soxZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=266 Paracoccus denitrificans]), soxY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=266 Paracoccus denitrificans]) | ||
| + | }} | ||
| + | |||
| + | '''The SOXYZ Complex of Paracoccus Pantotrophus''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2OXH is a [ | + | 2OXH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Paracoccus_denitrificans Paracoccus denitrificans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OXH OCA]. |
==Reference== | ==Reference== | ||
| - | The SoxYZ complex carries sulfur cycle intermediates on a peptide swinging arm., Sauve V, Bruno S, Berks BC, Hemmings AM, J Biol Chem. 2007 Aug 10;282(32):23194-204. Epub 2007 May 23. PMID:[http:// | + | The SoxYZ complex carries sulfur cycle intermediates on a peptide swinging arm., Sauve V, Bruno S, Berks BC, Hemmings AM, J Biol Chem. 2007 Aug 10;282(32):23194-204. Epub 2007 May 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17522046 17522046] |
[[Category: Paracoccus denitrificans]] | [[Category: Paracoccus denitrificans]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: immunoglobulin-like beta-sandwich fold]] | [[Category: immunoglobulin-like beta-sandwich fold]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:05:50 2008'' |
Revision as of 16:05, 20 March 2008
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| , resolution 2.35Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | soxZ (Paracoccus denitrificans), soxY (Paracoccus denitrificans) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
The SOXYZ Complex of Paracoccus Pantotrophus
Overview
The bacterial Sox (sulfur oxidizing) system allows the utilization of inorganic sulfur compounds in energy metabolism. Central to this process is the SoxYZ complex that carries the pathway intermediates on a cysteine residue near the C terminus of SoxY. Crystal structures have been determined for Paracoccus pantotrophus SoxYZ with the carrier cysteine in the underivatized state, conjugated to the polysulfide mimic beta-mercaptoethanol, and as the sulfonate adduct pathway intermediate. The carrier cysteine is located on a peptide swinging arm and is bracketed on either side by diglycine dipeptides acting as molecular universal joints. This structure provides a novel solution to the requirement that the cysteine-bound intermediates be able to access and orient themselves within the active sites of multiple partner enzymes. Adjacent to the swinging arm there is a conserved, deep, apolar pocket into which the beta-mercaptoethanol adduct extends. This pocket would be well suited to a role in protecting labile pathway intermediates from adventitious reactions.
About this Structure
2OXH is a Protein complex structure of sequences from Paracoccus denitrificans. Full crystallographic information is available from OCA.
Reference
The SoxYZ complex carries sulfur cycle intermediates on a peptide swinging arm., Sauve V, Bruno S, Berks BC, Hemmings AM, J Biol Chem. 2007 Aug 10;282(32):23194-204. Epub 2007 May 23. PMID:17522046
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