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2oxz

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[[Image:2oxz.jpg|left|200px]]<br /><applet load="2oxz" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2oxz.jpg|left|200px]]
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caption="2oxz, resolution 1.90&Aring;" />
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'''Human MMP-12 in complex with two peptides PQG and IAG'''<br />
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{{Structure
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|PDB= 2oxz |SIZE=350|CAPTION= <scene name='initialview01'>2oxz</scene>, resolution 1.90&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65]
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|GENE= MMP12, HME ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Human MMP-12 in complex with two peptides PQG and IAG'''
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==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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2OXZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OXZ OCA].
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2OXZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OXZ OCA].
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==Reference==
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Snapshots of the reaction mechanism of matrix metalloproteinases., Bertini I, Calderone V, Fragai M, Luchinat C, Maletta M, Yeo KJ, Angew Chem Int Ed Engl. 2006 Dec 4;45(47):7952-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17096442 17096442]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Macrophage elastase]]
[[Category: Macrophage elastase]]
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[[Category: mmp-12]]
[[Category: mmp-12]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:23:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:06:04 2008''

Revision as of 16:06, 20 March 2008

Image:2oxz.jpg


PDB ID 2oxz

Drag the structure with the mouse to rotate
, resolution 1.90Å
Ligands: and
Gene: MMP12, HME (Homo sapiens)
Activity: Macrophage elastase, with EC number 3.4.24.65
Coordinates: save as pdb, mmCIF, xml



Human MMP-12 in complex with two peptides PQG and IAG


Disease

Known diseases associated with this structure: Cardiomyopathy, dilated, 1G OMIM:[188840], Cardiomyopathy, familial hypertrophic OMIM:[188840], Muscular dystrophy, limb-girdle, type 2J OMIM:[188840], Myopathy, early-onset, with fatal cardiomyopathy OMIM:[188840], Myopathy, proximal, with early respiratory muscle involvement OMIM:[188840], Tibial muscular dystrophy, tardive OMIM:[188840]

About this Structure

2OXZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Mar 20 18:06:04 2008

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