2j38
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 2J38 is a | + | 2J38 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA and GS5 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J38 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: zymogen]] | [[Category: zymogen]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 14:07:30 2007'' |
Revision as of 12:02, 5 November 2007
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CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX
Overview
Torsional scans of sulfonamide S-C bonds in small model systems of a, series of arylsulfonamide factor Xa inhibitors were performed in order to, investigate if conformational effects can help to rationalise the observed, SAR. Computational results were in good agreement with the experimental, data indicating that the sulfonamide conformation plays an important role, in determining the activity in this particular series of factor Xa, inhibitors.
About this Structure
2J38 is a Single protein structure of sequence from Homo sapiens with CA and GS5 as ligands. Active as Coagulation factor Xa, with EC number 3.4.21.6 Structure known Active Site: AC1. Full crystallographic information is available from OCA.
Reference
Arylsulfonamides: a study of the relationship between activity and conformational preferences for a series of factor Xa inhibitors., Senger S, Convery MA, Chan C, Watson NS, Bioorg Med Chem Lett. 2006 Nov 15;16(22):5731-5. Epub 2006 Sep 18. PMID:16982192
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Categories: Coagulation factor Xa | Homo sapiens | Single protein | Chan, C. | Convery, M.A. | Senger, S. | Watson, N.S. | CA | GS5 | Blood coagulation | Calcium | Complex | Egf-like domain | Gamma- carboxyglutamic acid | Gamma-carboxyglutamic acid | Glycoprotein | Hydrolase | Hydroxylation | Polymorphism | Protease | Serine protease | Zymogen
