4o6d
From Proteopedia
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| - | + | ==West Nile Virus Non-structural protein 1 (NS1) Form 1 crystal== | |
| - | + | <StructureSection load='4o6d' size='340' side='right' caption='[[4o6d]], [[Resolution|resolution]] 2.59Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4o6d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Wnv Wnv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O6D FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OXN:OXTOXYNOL-10'>OXN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4o6b|4o6b]], [[4o6c|4o6c]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11082 WNV])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o6d RCSB], [http://www.ebi.ac.uk/pdbsum/4o6d PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Flaviviruses, the human pathogens responsible for dengue fever, West Nile fever, tick-borne encephalitis and yellow fever, are endemic in tropical and temperate parts of the world. The flavivirus non-structural protein 1 (NS1) functions in genome replication as an intracellular dimer and in immune system evasion as a secreted hexamer. We report crystal structures for full-length, glycosylated NS1 from West Nile and dengue viruses. The NS1 hexamer in crystal structures is similar to a solution hexamer visualized by single-particle electron microscopy. Recombinant NS1 binds to lipid bilayers and remodels large liposomes into lipoprotein nano-particles. The NS1 structures reveal distinct domains for membrane association of the dimer and interactions with the immune system, and are a basis for elucidating the molecular mechanism of NS1 function. | ||
| - | + | Flavivirus NS1 Structures Reveal Surfaces for Associations with Membranes and the Immune System.,Akey DL, Brown WC, Dutta S, Konwerski J, Jose J, Jurkiw TJ, Delproposto J, Ogata CM, Skiniotis G, Kuhn RJ, Smith JL Science. 2014 Feb 6. PMID:24505133<ref>PMID:24505133</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Akey, D L | + | == References == |
| - | [[Category: Smith, J L | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Wnv]] | ||
| + | [[Category: Akey, D L]] | ||
| + | [[Category: Smith, J L]] | ||
[[Category: Flavivirus]] | [[Category: Flavivirus]] | ||
[[Category: Non-structural protein 1]] | [[Category: Non-structural protein 1]] | ||
[[Category: Ns1]] | [[Category: Ns1]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
Revision as of 06:45, 22 January 2015
West Nile Virus Non-structural protein 1 (NS1) Form 1 crystal
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