2j3p

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Revision as of 12:02, 5 November 2007

Image:2j3p.gif

2j3p, resolution 1.40Å

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CRYSTAL STRUCTURE OF RAT FGF1 AT 1.4 A

Overview

Fibroblast growth factors (FGFs) constitute a family of 22 structurally, related heparin-binding polypeptides that are involved in the regulation, of cell growth, survival, differentiation and migration. Here, a 1.4 A, resolution X-ray structure of rat FGF1 is presented. Two molecules are, present in the asymmetric unit of the crystal and they coordinate a total, of five sulfate ions. The structures of human, bovine and newt FGF1 have, been published previously. Human and rat FGF1 are found to have very, similar structures.

About this Structure

2J3P is a Single protein structure of sequence from Rattus norvegicus with SO4 as ligand. Structure known Active Site: AC1. Full crystallographic information is available from OCA.

Reference

Structure of rat acidic fibroblast growth factor at 1.4 A resolution., Kulahin N, Kiselyov V, Kochoyan A, Kristensen O, Kastrup JS, Berezin V, Bock E, Gajhede M, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2007 Feb 1;63(Pt, 2):65-8. Epub 2007 Jan 27. PMID:17277441

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