2p4d
From Proteopedia
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| - | [[Image:2p4d.jpg|left|200px]] | + | [[Image:2p4d.jpg|left|200px]] |
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| - | '''Structure-assisted discovery of Variola major H1 phosphatase inhibitors''' | + | {{Structure |
| + | |PDB= 2p4d |SIZE=350|CAPTION= <scene name='initialview01'>2p4d</scene>, resolution 1.800Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Structure-assisted discovery of Variola major H1 phosphatase inhibitors''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2P4D is a [ | + | 2P4D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Variola_virus Variola virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P4D OCA]. |
==Reference== | ==Reference== | ||
| - | Structure-assisted discovery of Variola major H1 phosphatase inhibitors., Phan J, Tropea JE, Waugh DS, Acta Crystallogr D Biol Crystallogr. 2007 Jun;63(Pt 6):698-704. Epub 2007, May 15. PMID:[http:// | + | Structure-assisted discovery of Variola major H1 phosphatase inhibitors., Phan J, Tropea JE, Waugh DS, Acta Crystallogr D Biol Crystallogr. 2007 Jun;63(Pt 6):698-704. Epub 2007, May 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17505108 17505108] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Variola virus]] | [[Category: Variola virus]] | ||
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[[Category: small pox]] | [[Category: small pox]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:08:30 2008'' |
Revision as of 16:08, 20 March 2008
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| , resolution 1.800Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure-assisted discovery of Variola major H1 phosphatase inhibitors
Overview
Variola major virus, the causative agent of smallpox, encodes the dual-specificity H1 phosphatase. Because this enzyme is essential for the production of mature virus particles, it is an attractive molecular target for the development of therapeutic countermeasures for this potential agent of bioterrorism. As a first step in this direction, the crystal structure of H1 phosphatase has been determined at a resolution of 1.8 A. In silico screening methods have led to the identification of several small molecules that inhibit Variola H1 phosphatase with IC(50) values in the low micromolar range. These molecules provide novel leads for future drug development.
About this Structure
2P4D is a Single protein structure of sequence from Variola virus. Full crystallographic information is available from OCA.
Reference
Structure-assisted discovery of Variola major H1 phosphatase inhibitors., Phan J, Tropea JE, Waugh DS, Acta Crystallogr D Biol Crystallogr. 2007 Jun;63(Pt 6):698-704. Epub 2007, May 15. PMID:17505108
Page seeded by OCA on Thu Mar 20 18:08:30 2008
