2p59

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[[Image:2p59.jpg|left|200px]]<br /><applet load="2p59" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2p59.jpg|left|200px]]
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caption="2p59, resolution 2.900&Aring;" />
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'''Crystal Structure of Hepatitis C Virus NS3.4A protease'''<br />
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{{Structure
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|PDB= 2p59 |SIZE=350|CAPTION= <scene name='initialview01'>2p59</scene>, resolution 2.900&Aring;
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|SITE= <scene name='pdbsite=AC1:Gg4+Binding+Site+For+Residue+B+1208'>AC1</scene>
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|LIGAND= <scene name='pdbligand=GG4:'>GG4</scene>
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|ACTIVITY=
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|GENE= NS3 protease domain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=54290 GB virus C])
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}}
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'''Crystal Structure of Hepatitis C Virus NS3.4A protease'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2P59 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gb_virus_c Gb virus c] with <scene name='pdbligand=GG4:'>GG4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Gg4+Binding+Site+For+Residue+B+1208'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P59 OCA].
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2P59 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gb_virus_c Gb virus c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P59 OCA].
==Reference==
==Reference==
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Inhibitors of hepatitis C virus NS3.4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics., Perni RB, Chandorkar G, Cottrell KM, Gates CA, Lin C, Lin K, Luong YP, Maxwell JP, Murcko MA, Pitlik J, Rao G, Schairer WC, Van Drie J, Wei Y, Bioorg Med Chem Lett. 2007 Jun 15;17(12):3406-11. Epub 2007 Apr 3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17482818 17482818]
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Inhibitors of hepatitis C virus NS3.4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics., Perni RB, Chandorkar G, Cottrell KM, Gates CA, Lin C, Lin K, Luong YP, Maxwell JP, Murcko MA, Pitlik J, Rao G, Schairer WC, Van Drie J, Wei Y, Bioorg Med Chem Lett. 2007 Jun 15;17(12):3406-11. Epub 2007 Apr 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17482818 17482818]
[[Category: Gb virus c]]
[[Category: Gb virus c]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: viral protein]]
[[Category: viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:25:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:08:50 2008''

Revision as of 16:08, 20 March 2008

Image:2p59.jpg


PDB ID 2p59

Drag the structure with the mouse to rotate
, resolution 2.900Å
Sites:
Ligands:
Gene: NS3 protease domain (GB virus C)
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Hepatitis C Virus NS3.4A protease


Overview

Reversible tetrapeptide-based compounds have been shown to effectively inhibit the hepatitis C virus NS3.4A protease. Inhibition of viral replicon RNA production in Huh-7 cells has also been demonstrated. We show herein that the inclusion of hydrogen bond donors on the P4 capping group of tetrapeptide-based inhibitors result in increased binding potency to the NS3.4A protease. The capping groups also impart significant effects on the pharmacokinetic profile of these inhibitors.

About this Structure

2P59 is a Single protein structure of sequence from Gb virus c. Full crystallographic information is available from OCA.

Reference

Inhibitors of hepatitis C virus NS3.4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics., Perni RB, Chandorkar G, Cottrell KM, Gates CA, Lin C, Lin K, Luong YP, Maxwell JP, Murcko MA, Pitlik J, Rao G, Schairer WC, Van Drie J, Wei Y, Bioorg Med Chem Lett. 2007 Jun 15;17(12):3406-11. Epub 2007 Apr 3. PMID:17482818

Page seeded by OCA on Thu Mar 20 18:08:50 2008

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