2ar0

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Revision as of 10:23, 25 January 2015

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 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ar0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ar0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ar0 RCSB], [http://www.ebi.ac.uk/pdbsum/2ar0 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/2ar0 TOPSAN]</span></td></tr>
 </table>
+== Function ==
+[[http://www.uniprot.org/uniprot/T1MK_ECOLI T1MK_ECOLI]] The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated. The EcoKI enzyme recognizes 5'-AACN(6)GTGC-3'.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]