2yq2
From Proteopedia
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| - | [[ | + | ==Structure of BVDV1 envelope glycoprotein E2, pH8== |
| + | <StructureSection load='2yq2' size='340' side='right' caption='[[2yq2]], [[Resolution|resolution]] 2.58Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2yq2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_viral_diarrhea_virus_1 Bovine viral diarrhea virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YQ2 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yq3|2yq3]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yq2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yq2 RCSB], [http://www.ebi.ac.uk/pdbsum/2yq2 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Enveloped viruses have developed various adroit mechanisms to invade their host cells. This process requires one or more viral envelope glycoprotein to achieve cell attachment and membrane fusion. Members of the Flaviviridae such as flaviviruses possess only one envelope glycoprotein, E, whereas pestiviruses and hepacivirus encode two glycoproteins, E1 and E2. Although E2 is involved in cell attachment, it has been unclear which protein is responsible for membrane fusion. We report the crystal structures of the homodimeric glycoprotein E2 from the pestivirus bovine viral diarrhea virus 1 (BVDV1) at both neutral and low pH. Unexpectedly, BVDV1 E2 does not have a class II fusion protein fold, and at low pH the N-terminal domain is disordered, similarly to the intermediate postfusion state of E2 from sindbis virus, an alphavirus. Our results suggest that the pestivirus and possibly the hepacivirus fusion machinery are unlike any previously observed. | ||
| - | + | Structure of a Pestivirus Envelope Glycoprotein E2 Clarifies Its Role in Cell Entry.,El Omari K, Iourin O, Harlos K, Grimes JM, Stuart DI Cell Rep. 2012 Dec 26. pii: S2211-1247(12)00424-X. doi:, 10.1016/j.celrep.2012.12.001. PMID:23273918<ref>PMID:23273918</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | + | </StructureSection> | |
[[Category: Bovine viral diarrhea virus 1]] | [[Category: Bovine viral diarrhea virus 1]] | ||
| - | [[Category: Grimes, J M | + | [[Category: Grimes, J M]] |
| - | [[Category: Harlos, K | + | [[Category: Harlos, K]] |
| - | [[Category: Iourin, O | + | [[Category: Iourin, O]] |
| - | [[Category: Omari, K El | + | [[Category: Omari, K El]] |
| - | [[Category: Stuart, D I | + | [[Category: Stuart, D I]] |
[[Category: Pestivirus]] | [[Category: Pestivirus]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
[[Category: Virus fusion]] | [[Category: Virus fusion]] | ||
Revision as of 05:01, 27 January 2015
Structure of BVDV1 envelope glycoprotein E2, pH8
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