4ry3

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'''Unreleased structure'''
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==Crystal structure of human Fanconi-associated nuclease 1==
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<StructureSection load='4ry3' size='340' side='right' caption='[[4ry3]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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The entry 4ry3 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ry3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RY3 FirstGlance]. <br>
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Authors: Yan, P.X., Huo, Y.G., Jiang, T.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ry3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ry3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ry3 RCSB], [http://www.ebi.ac.uk/pdbsum/4ry3 PDBsum]</span></td></tr>
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Description: Crystal structure of human Fanconi-associated nuclease 1
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</table>
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[[Category: Unreleased Structures]]
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== Disease ==
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[[Category: Yan, P.X]]
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[[http://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN]] Karyomegalic interstitial nephritis. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN]] Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template.<ref>PMID:20603015</ref> <ref>PMID:20603016</ref> <ref>PMID:20603073</ref> <ref>PMID:20671156</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Huo, Y G]]
[[Category: Jiang, T]]
[[Category: Jiang, T]]
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[[Category: Huo, Y.G]]
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[[Category: Yan, P X]]
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[[Category: Endonuclease 5'-3'exonulease]]
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[[Category: Fan1]]
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[[Category: Fancd2]]
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[[Category: Hydrolase]]

Revision as of 16:34, 28 January 2015

Crystal structure of human Fanconi-associated nuclease 1

4ry3, resolution 2.80Å

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