4ret
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of the Na,K-ATPase E2P-digoxin complex with bound magnesium== |
| - | + | <StructureSection load='4ret' size='340' side='right' caption='[[4ret]], [[Resolution|resolution]] 4.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4ret]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RET OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RET FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=17F:O-[(S)-({(2R)-2,3-BIS[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL}OXY)(HYDROXY)PHOSPHORYL]-L-SERINE'>17F</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=DGX:DIGOXIN'>DGX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SUC:SUCROSE'>SUC</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PHD:ASPARTYL+PHOSPHATE'>PHD</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hyt|4hyt]], [[3n23|3n23]], [[4res|4res]]</td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sodium/potassium-exchanging_ATPase Sodium/potassium-exchanging ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.9 3.6.3.9] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ret FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ret OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ret RCSB], [http://www.ebi.ac.uk/pdbsum/4ret PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AT1A1_PIG AT1A1_PIG]] This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. [[http://www.uniprot.org/uniprot/AT1B1_PIG AT1B1_PIG]] This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Sodium/potassium-exchanging ATPase]] | ||
| + | [[Category: Sus scrofa]] | ||
| + | [[Category: Fedosova, N U]] | ||
| + | [[Category: Gregersen, J L]] | ||
[[Category: Laursen, M]] | [[Category: Laursen, M]] | ||
| - | [[Category: Gregersen, J.L]] | ||
[[Category: Nissen, P]] | [[Category: Nissen, P]] | ||
| - | [[Category: Fedosova, N.U]] | ||
[[Category: Yatime, L]] | [[Category: Yatime, L]] | ||
| + | [[Category: Alpha-helical transmembrane protein]] | ||
| + | [[Category: Atp binding]] | ||
| + | [[Category: Atpase]] | ||
| + | [[Category: Glycosylation]] | ||
| + | [[Category: Hydrolase-inhibitor complex]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Multisubunit complex]] | ||
| + | [[Category: Phosphorylation]] | ||
| + | [[Category: Plasma membrane]] | ||
| + | [[Category: Potassium binding]] | ||
| + | [[Category: Potassium ion transport]] | ||
| + | [[Category: Receptor for cardiotonic steroid]] | ||
| + | [[Category: Sodium binding]] | ||
| + | [[Category: Sodium ion transport]] | ||
| + | [[Category: Trimeric complex]] | ||
Revision as of 16:46, 28 January 2015
Crystal structure of the Na,K-ATPase E2P-digoxin complex with bound magnesium
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Categories: Sodium/potassium-exchanging ATPase | Sus scrofa | Fedosova, N U | Gregersen, J L | Laursen, M | Nissen, P | Yatime, L | Alpha-helical transmembrane protein | Atp binding | Atpase | Glycosylation | Hydrolase-inhibitor complex | Membrane protein | Multisubunit complex | Phosphorylation | Plasma membrane | Potassium binding | Potassium ion transport | Receptor for cardiotonic steroid | Sodium binding | Sodium ion transport | Trimeric complex
