4rv7
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Characterization of an essential diadenylate cyclase== |
| - | + | <StructureSection load='4rv7' size='340' side='right' caption='[[4rv7]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4rv7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RV7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diadenylate_cyclase Diadenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.85 2.7.7.85] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rv7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rv7 RCSB], [http://www.ebi.ac.uk/pdbsum/4rv7 PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DACA_LISMO DACA_LISMO]] Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a signaling compound secreted into the host's cytosol where it triggers the cytosolic surveillance pathway (CSP), a host pathway of innate immunity characterized by expression of beta interferon (IFN-beta) and coregulated genes.<ref>PMID:20508090</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Diadenylate cyclase]] | ||
[[Category: Dickmanns, A]] | [[Category: Dickmanns, A]] | ||
[[Category: Ficner, R]] | [[Category: Ficner, R]] | ||
[[Category: Neumann, P]] | [[Category: Neumann, P]] | ||
| + | [[Category: Atp binding]] | ||
| + | [[Category: C-di-amp binding]] | ||
| + | [[Category: Dac-fold]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 16:47, 28 January 2015
Characterization of an essential diadenylate cyclase
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