Ankyrin
From Proteopedia
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**[[2yqf]], [[2yvi]] – hANK-1 death domain – NMR<br /> | **[[2yqf]], [[2yvi]] – hANK-1 death domain – NMR<br /> | ||
**[[3f59]] – hANK-1 spectrin-binding domain<br /> | **[[3f59]] – hANK-1 spectrin-binding domain<br /> | ||
| - | **[[ | + | **[[3ud1]], [[3ud2]] - hANK-1 zu5a-zu5b domains<br /> |
**[[4d8o]] - hANK-1 zu5a-zu5b-upa-dd domains<br /> | **[[4d8o]] - hANK-1 zu5a-zu5b-upa-dd domains<br /> | ||
| + | **[[406x]] - hANK-3 death domain<br /> | ||
**[[3kbt]], [[3kbu]] - hANK-1 residues 911-1068 + spectrin β chain<br /> | **[[3kbt]], [[3kbu]] - hANK-1 residues 911-1068 + spectrin β chain<br /> | ||
| + | **[[4rlv]] - hANK-1 + hANK-2<br /> | ||
**[[3so8]] – hANK-A residues 149-310<br /> | **[[3so8]] – hANK-A residues 149-310<br /> | ||
**[[1n0q]], [[1n0r]], [[2bkg]], [[2qyj]] – dANK repeats – designed<br /> | **[[1n0q]], [[1n0r]], [[2bkg]], [[2qyj]] – dANK repeats – designed<br /> | ||
Revision as of 09:14, 1 February 2015
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Ankyrins (ANK) are proteins which mediate the attachment of membrane proteins to the membrane skeleton. Ankyrin contains four domains: the N terminal which contains 24 ankyrin repeats, a spectrin-binding domain, a death domain which binds to proteins involved in apoptosis and a C terminal regulatory domain. ANKRD2 belongs to the conserved muscle ankyrin repeat protein (MARP) family.Also known as Arpp or stretch responsive muscle ANKRD2 gene contains 9 exons and spans about 12 kb. The 5-prime flanking region contains a TATA box and binding motifs for the muscle-specific transcription factors MYOD and for NF-kappa-B.
Kemp et.al cloned mouse Ankrd2 and obtained a partial human ANKRD2 cDNA. The full-length 328-amino acid mouse protein contains an ATP/GTP-binding domain in its N-terminal half and an ankyrin repeat region in its C-terminal half. It also has a nuclear localization signal, 2 protein-destabilizing PEST sequences, and 2 phosphorylation sites. Northern blot and PCR analyses detected expression of mouse Ankrd2 only in tissues containing striated muscle. In situ hybridization of mouse embryos showed that Ankrd2 expression was restricted to the myotome of somites at day 9.5. At later developmental stages, Ankrd2 expression was stronger in outer back muscles than intercostal muscles, and it was not expressed in heart. See also
3D Structures of Ankyrin
Updated on 01-February-2015
