Arylamine N-acetyltransferase
From Proteopedia
(Difference between revisions)
| Line 17: | Line 17: | ||
**[[1gx3]] – MsNAT – ''Mycobacterium smegmatis''<br /> | **[[1gx3]] – MsNAT – ''Mycobacterium smegmatis''<br /> | ||
**[[1w5r]] – MsNAT (mutant)<br /> | **[[1w5r]] – MsNAT (mutant)<br /> | ||
| - | **[[2bsz]] – | + | **[[2bsz]] – RlNAT1 – ''Rhizobium loti''<br /> |
| + | **[[4nv8]] – RlNAT (mutant)<br /> | ||
**[[2ija]] – hNAT1 (mutant) – human<br /> | **[[2ija]] – hNAT1 (mutant) – human<br /> | ||
**[[2pqt]] - hNAT1<br /> | **[[2pqt]] - hNAT1<br /> | ||
| Line 32: | Line 33: | ||
**[[3ltw]] – MmNAT + hydralazine<br /> | **[[3ltw]] – MmNAT + hydralazine<br /> | ||
**[[1w6f]] – MsNAT + anti-tubercular drug<br /> | **[[1w6f]] – MsNAT + anti-tubercular drug<br /> | ||
| + | **[[4b55]] – MmNAT + piperidinol derivative<br /> | ||
| + | **[[4nv7]] – RlNAT + CoA<br /> | ||
| + | |||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:42, 2 February 2015
Arylamine N-acetyltransferase (NAT) catalyzes the transfer of an acetyl group from acetyl-CoA to an arylamine. Acetylation is a major route of biotransformation for many arylamines and hydrazine drugs and known carcinogens like cigarette smoke. The levels of NAT in the body has important consequences with regard to an individual’s susceptibility to certain drug-induced toxicities and cancer.
3D structures of arylamine N-acetyltransferase
Updated on 02-February-2015
