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Asparaginase
From Proteopedia
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**[[1hfj]], [[1hfk]], [[1o7j]] - ErcASP – ''Erwinia chrysanthemi''<br /> | **[[1hfj]], [[1hfk]], [[1o7j]] - ErcASP – ''Erwinia chrysanthemi''<br /> | ||
| - | **[[1wnf]] - ASP – ''Pyrococcus horikoshii''<br /> | + | **[[1wnf]], [[1wls]] - ASP – ''Pyrococcus horikoshii''<br /> |
**[[1zcf]] - PaASP – ''Pectobacterium atrosepticum''<br /> | **[[1zcf]] - PaASP – ''Pectobacterium atrosepticum''<br /> | ||
**[[2gez]] - ASP – yellow lupine<br /> | **[[2gez]] - ASP – yellow lupine<br /> | ||
| Line 18: | Line 18: | ||
**[[3ntx]] - ASP – ''Yersinia pestis''<br /> | **[[3ntx]] - ASP – ''Yersinia pestis''<br /> | ||
**[[3nxk]] - ASP – ''Campylobacter jejuni''<br /> | **[[3nxk]] - ASP – ''Campylobacter jejuni''<br /> | ||
| - | **[[4gdu]] - hASP – human | + | **[[4gdu]] - hASP – human<br /> |
| + | **[[4pu6]], [[4pv2]], [[4pv3]] – ASP – bean<br /> | ||
| + | **[[4q0m]], [[4ra6]], [[4ra9]] – ASP – ''Pyrococcus furiosus''<br /> | ||
| + | |||
*ASP I complex | *ASP I complex | ||
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**[[4gdt]] - hASP + malonate<br /> | **[[4gdt]] - hASP + malonate<br /> | ||
**[[4gdv]], [[4gdw]] - hASP + AA<BR /> | **[[4gdv]], [[4gdw]] - hASP + AA<BR /> | ||
| + | **[[4nje]] – ASP + Asp – ''Pyrococcus horikoshii''<br /> | ||
*ASP II | *ASP II | ||
Revision as of 10:58, 2 February 2015
Asparaginase (ASP) catalyzes the conversion of asparagine to aspartic acid (AA). ASP I is used in the food processing industry to reduce the formation of the carcinogen acrylamide in the production of starchy food products. A different kind of ASP – ASP II – is used as drug (Elspar) in the treatment of cancer such as acute lymphoblastic leukemia (ALL). The ALL cells require high concentrations of asparagine which becomes scarce when high doses of ASP are present.
3D structures of asparaginase
Updated on 02-February-2015
Proteopedia Page Contributors and Editors (what is this?)
Joel L. Sussman, Michal Harel, Alexander Berchansky, Jaime Prilusky
