Aspartate decarboxylase

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== Function ==
== Function ==
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'''Aspartate decarboxylase''' (ADC) catalyzes the conversion of L-aspartate to β-alanine and CO2. ADC is a pyruvate-dependent enzyme which is synthesized as an inactive protein. The ADC precursor is cleaved to the active α and β subunits.
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'''Aspartate 1-decarboxylase''' or '''aspartate α-decarboxylase''' (AADC) catalyzes the conversion of L-aspartate to β-alanine and CO2. '''Aspartate 4-decarboxylase''' or '''aspartate β-decarboxylase''' (ABDC) catalyzes the conversion of L-aspartate to L-alanine and CO2. AADC is a pyruvate-dependent enzyme which is synthesized as an inactive protein. The AADC precursor is cleaved to the active α and β subunits. ABDC is a pyridoxal-5’-phosphate (PLP)-dependent enzyme.
== Disease ==
== Disease ==
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*Aspartate decarboxylase
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*Aspartate α-decarboxylase
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**[[1aw8]], [[1pt0]], [[1pyq]] – EcADC – ''Escherichia coli''<br />
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**[[1aw8]], [[1pt0]], [[1pyq]] – EcAADC – ''Escherichia coli''<br />
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**[[1pt1]], [[1pqe]], [[1pqf]], [[1pqh]], [[1pyu]], [[3tm7]], [[4azd]] – EcADC (mutant)<br />
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**[[1pt1]], [[1pqe]], [[1pqf]], [[1pqh]], [[1pyu]], [[3tm7]], [[4azd]] – EcAADC (mutant)<br />
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**[[1ppy]] – EcADC precursor<br />
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**[[1ppy]] – EcAADC precursor<br />
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**[[1vc3]] – TtADC – ''Thermus thermophilus''<br />
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**[[1vc3]] – TtAADC – ''Thermus thermophilus''<br />
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**[[2c45]] – ADC – ''Mycobacterium tuberculosis''<br />
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**[[2c45]] – AADC – ''Mycobacterium tuberculosis''<br />
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**[[3oug]] – ADC – ''Francesella tularensis''<br />
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**[[3oug]] – AADC – ''Francesella tularensis''<br />
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**[[3plx]] – ADC – ''Campylobacter jejuni'' <br />
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**[[3plx]] – AADC – ''Campylobacter jejuni'' <br />
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*Aspartate decarboxylase complexes
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*Aspartate α-decarboxylase complexes
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**[[1uhd]] – HpAADC + pyruvate – ''Helicobacter pylori''<br />
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**[[1uhe]] – HpAADC + isoasparagine<br />
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**[[2eeo]] – TtAADC + pyruvate + fumarate<br />
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**[[4aok]], [[4aon]] – EcAADC + methyl aspartate derivative<br />
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*Aspartate β-decarboxylase
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**[[2zy2]], [[3fdd]] – ABDC + PLP – ''Pseudomonas''<br />
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**[[2zy3]], [[2zy4]] – AfABDC + PLP – ''Alcaligenes faecalis''<br />
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**[[2zy5]] – AfABDC (mutant) +PLP<br />
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**[[1uhd]] – HpADC + pyruvate – ''Helicobacter pylori''<br />
 
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**[[1uhe]] – HpADC + isoasparagine<br />
 
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**[[2eeo]] – TtADC + pyruvate + fumarate<br />
 
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**[[4aok]], [[4aon]] – EcADC + methyl aspartate derivative<br />
 
}}
}}

Revision as of 12:53, 2 February 2015

Structure of aspartate decarboxylase α (grey) and β subunits complex with pyruvate (PDB code 1uhd).

Drag the structure with the mouse to rotate

3D structures of aspartate decarboxylase

Updated on 02-February-2015

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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