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2phw
From Proteopedia
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| - | [[Image:2phw.jpg|left|200px]] | + | [[Image:2phw.jpg|left|200px]] |
| - | + | ||
| - | '''Pterocarpus angolensis lectin (PAL) in complex with Man-9''' | + | {{Structure |
| + | |PDB= 2phw |SIZE=350|CAPTION= <scene name='initialview01'>2phw</scene>, resolution 1.8Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Pterocarpus angolensis lectin (PAL) in complex with Man-9''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2PHW is a [ | + | 2PHW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PHW OCA]. |
==Reference== | ==Reference== | ||
| - | How a plant lectin recognizes high mannose oligosaccharides., Garcia-Pino A, Buts L, Wyns L, Imberty A, Loris R, Plant Physiol. 2007 Aug;144(4):1733-41. Epub 2007 Jun 7. PMID:[http:// | + | How a plant lectin recognizes high mannose oligosaccharides., Garcia-Pino A, Buts L, Wyns L, Imberty A, Loris R, Plant Physiol. 2007 Aug;144(4):1733-41. Epub 2007 Jun 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17556509 17556509] |
[[Category: Pterocarpus angolensis]] | [[Category: Pterocarpus angolensis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: lectin]] | [[Category: lectin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:13:09 2008'' |
Revision as of 16:13, 20 March 2008
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| , resolution 1.8Å | |||||||
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| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Pterocarpus angolensis lectin (PAL) in complex with Man-9
Overview
The crystal structure of Pterocarpus angolensis seed lectin is presented in complex with a series of high mannose (Man) oligosaccharides ranging from Man-5 to Man-9. Despite that several of the nine Man residues of Man-9 have the potential to bind in the monosaccharide-binding site, all oligomannoses are bound in the same unique way, employing the tetrasaccharide sequence Manalpha(1-2)Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-. Isothermal titration calorimetry titration experiments using Man-5, Man-9, and the Man-9-containing glycoprotein soybean (Glycine max) agglutinin as ligands confirm the monovalence of Man-9 and show a 4-times higher affinity for Man-9 when it is presented to P. angolensis seed lectin in a glycoprotein context.
About this Structure
2PHW is a Single protein structure of sequence from Pterocarpus angolensis. Full crystallographic information is available from OCA.
Reference
How a plant lectin recognizes high mannose oligosaccharides., Garcia-Pino A, Buts L, Wyns L, Imberty A, Loris R, Plant Physiol. 2007 Aug;144(4):1733-41. Epub 2007 Jun 7. PMID:17556509
Page seeded by OCA on Thu Mar 20 18:13:09 2008
Categories: Pterocarpus angolensis | Single protein | Buts, L. | Garcia-Pino, A. | Imberty, A. | Loris, R. | Wyns, L. | CA | MN | Carbohydrate | High mannose | Lectin
