2pl4
From Proteopedia
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| - | [[Image:2pl4.gif|left|200px]] | + | [[Image:2pl4.gif|left|200px]] |
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| - | '''D-(GGTATACC) under 0.55 GPa hydrostatic pressure''' | + | {{Structure |
| + | |PDB= 2pl4 |SIZE=350|CAPTION= <scene name='initialview01'>2pl4</scene>, resolution 1.65Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''D-(GGTATACC) under 0.55 GPa hydrostatic pressure''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2PL4 is a [ | + | 2PL4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PL4 OCA]. |
==Reference== | ==Reference== | ||
| - | Adaptation of the base-paired double-helix molecular architecture to extreme pressure., Girard E, Prange T, Dhaussy AC, Migianu-Griffoni E, Lecouvey M, Chervin JC, Mezouar M, Kahn R, Fourme R, Nucleic Acids Res. 2007;35(14):4800-8. Epub 2007 Jul 7. PMID:[http:// | + | Adaptation of the base-paired double-helix molecular architecture to extreme pressure., Girard E, Prange T, Dhaussy AC, Migianu-Griffoni E, Lecouvey M, Chervin JC, Mezouar M, Kahn R, Fourme R, Nucleic Acids Res. 2007;35(14):4800-8. Epub 2007 Jul 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17617642 17617642] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Fourme, R.]] | [[Category: Fourme, R.]] | ||
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[[Category: high-pressure]] | [[Category: high-pressure]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:14:20 2008'' |
Revision as of 16:14, 20 March 2008
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| , resolution 1.65Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
D-(GGTATACC) under 0.55 GPa hydrostatic pressure
Overview
The behaviour of the d(GGTATACC) oligonucleotide has been investigated by X-ray crystallography at 295 K in the range from ambient pressure to 2 GPa (approximately 20,000 atm). Four 3D-structures of the A-DNA form (at ambient pressure, 0.55, 1.09 and 1.39 GPa) were refined at 1.60 or 1.65 A resolution. In addition to the diffraction pattern of the A-form, the broad meridional streaks previously explained by occluded B-DNA octamers within the channels of the crystalline A-form matrix were observed up to at least 2 GPa. This work highlights an important property of nucleic acids, their capability to withstand very high pressures, while keeping in such conditions a nearly invariant geometry of base pairs that store and carry genetic information. The double-helix base-paired architecture behaves as a molecular spring, which makes it especially adapted to very harsh conditions. These features may have contributed to the emergence of a RNA World at prebiotic stage.
About this Structure
2PL4 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Adaptation of the base-paired double-helix molecular architecture to extreme pressure., Girard E, Prange T, Dhaussy AC, Migianu-Griffoni E, Lecouvey M, Chervin JC, Mezouar M, Kahn R, Fourme R, Nucleic Acids Res. 2007;35(14):4800-8. Epub 2007 Jul 7. PMID:17617642
Page seeded by OCA on Thu Mar 20 18:14:20 2008
