3wsz

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'''Unreleased structure'''
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==SorLA Vps10p domain in complex with Abeta-derived peptide==
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<StructureSection load='3wsz' size='340' side='right' caption='[[3wsz]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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The entry 3wsz is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3wsz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WSZ FirstGlance]. <br>
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Authors: Kitago, Y., Nakata, Z., Nagae, M., Nogi, T., Takagi, J.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wsx|3wsx]], [[3wsy|3wsy]]</td></tr>
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Description: Neuronal extracellular receptor N-term domain with the ligand peptide
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wsz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wsz RCSB], [http://www.ebi.ac.uk/pdbsum/3wsz PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/SORL_HUMAN SORL_HUMAN]] Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.
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__TOC__
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</StructureSection>
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[[Category: Kitago, Y]]
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[[Category: Nagae, M]]
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[[Category: Nakata, Z]]
[[Category: Nogi, T]]
[[Category: Nogi, T]]
[[Category: Takagi, J]]
[[Category: Takagi, J]]
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[[Category: Nakata, Z]]
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[[Category: Beta-propeller]]
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[[Category: Nagae, M]]
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[[Category: Protein binding]]
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[[Category: Kitago, Y]]
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[[Category: Receptor]]

Revision as of 15:53, 7 February 2015

SorLA Vps10p domain in complex with Abeta-derived peptide

3wsz, resolution 3.20Å

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