4ow8

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'''Unreleased structure'''
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==Crystal structure of kinase domain of PknA from Mtb==
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<StructureSection load='4ow8' size='340' side='right' caption='[[4ow8]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
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The entry 4ow8 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ow8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OW8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OW8 FirstGlance]. <br>
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Authors: Ravala, S.K., Singh, S., Yadav, G.S., Karthikeyan, S., Chakraborti, P.K.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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Description: Crystal structure of kinase domain of PknA from Mtb
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ow8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ow8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ow8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ow8 PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Chakraborti, P.K]]
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== Function ==
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[[Category: Yadav, G.S]]
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[[http://www.uniprot.org/uniprot/PKNA_MYCTU PKNA_MYCTU]] Key component of a signal transduction pathway that regulates cell growth and cell division via phosphorylation of target proteins such as FtsZ, Wag31, GlmU, FhaB, PstP, EmbR and Rv1422. Shows a strong preference for Thr versus Ser as the phosphoacceptor.<ref>PMID:15985609</ref> <ref>PMID:16817899</ref> <ref>PMID:19121323</ref> <ref>PMID:20066037</ref> <ref>PMID:21190553</ref> <ref>PMID:21423706</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Chakraborti, P K]]
[[Category: Karthikeyan, S]]
[[Category: Karthikeyan, S]]
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[[Category: Ravala, S K]]
[[Category: Singh, S]]
[[Category: Singh, S]]
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[[Category: Ravala, S.K]]
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[[Category: Yadav, G S]]
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[[Category: Drug target]]
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[[Category: Kinase]]
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[[Category: Mtb]]
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[[Category: Pkna]]

Revision as of 15:56, 7 February 2015

Crystal structure of kinase domain of PknA from Mtb

4ow8, resolution 2.03Å

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