4ru2
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of a RNA-binding protein 39 (RBM39) in complex with fragment of splicing factor (U2AF) from Mus musculus at 2.20 A resolution== | |
| - | + | <StructureSection load='4ru2' size='340' side='right' caption='[[4ru2]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4ru2]] is a 18 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RU2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ru2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ru2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ru2 RCSB], [http://www.ebi.ac.uk/pdbsum/4ru2 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | [[ | + | [[http://www.uniprot.org/uniprot/RBM39_MOUSE RBM39_MOUSE]] Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1. May be involved in pre-mRNA splicing process.<ref>PMID:11704680</ref> [[http://www.uniprot.org/uniprot/U2AF2_MOUSE U2AF2_MOUSE]] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10 (By similarity). |
| - | [[ | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: TCELL, Partnership for T-Cell Biology]] | ||
| + | [[Category: Jcsg]] | ||
| + | [[Category: PSI, Protein structure initiative]] | ||
| + | [[Category: Psi-biology]] | ||
| + | [[Category: Rna binding protein]] | ||
Revision as of 15:58, 7 February 2015
Crystal structure of a RNA-binding protein 39 (RBM39) in complex with fragment of splicing factor (U2AF) from Mus musculus at 2.20 A resolution
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