4oni

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'''Unreleased structure'''
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==Structure of Human Orphan Receptor LRH1 bound to two bacterial phospholipids==
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<StructureSection load='4oni' size='340' side='right' caption='[[4oni]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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The entry 4oni is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4oni]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ONI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ONI FirstGlance]. <br>
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Authors: Gorman, M.A., Parker, M.W., Kusumo, S.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPH:L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE'>EPH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P6L:(2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL+(8E)-OCTADEC-8-ENOATE'>P6L</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yuc|1yuc]], [[1yok|1yok]]</td></tr>
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Description: Structure of Human Orphan Receptor LRH1 bound to two bacterial phospholipids
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oni OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oni RCSB], [http://www.ebi.ac.uk/pdbsum/4oni PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Gorman, M.A]]
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== Disease ==
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[[Category: Parker, M.W]]
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[[http://www.uniprot.org/uniprot/NR0B2_HUMAN NR0B2_HUMAN]] Defects in NR0B2 may be associated with obesity (OBESITY) [MIM:[http://omim.org/entry/601665 601665]]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:11136233</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN]] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. [[http://www.uniprot.org/uniprot/NR0B2_HUMAN NR0B2_HUMAN]] Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.<ref>PMID:14752053</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Gorman, M A]]
[[Category: Kusumo, S]]
[[Category: Kusumo, S]]
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[[Category: Parker, M W]]
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[[Category: Alpha helical sandwich fold]]
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[[Category: Co-factor binding]]
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[[Category: Nuclear protein]]
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[[Category: Nuclear receptor]]

Revision as of 11:57, 12 February 2015

Structure of Human Orphan Receptor LRH1 bound to two bacterial phospholipids

4oni, resolution 1.80Å

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