This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4rut
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ''' | + | ==crystal structure of murine cyclooxygenase-2 with 13-methyl-arachidonic Acid== |
| - | + | <StructureSection load='4rut' size='340' side='right' caption='[[4rut]], [[Resolution|resolution]] 2.16Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4rut]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RUT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=COH:PROTOPORPHYRIN+IX+CONTAINING+CO'>COH</scene>, <scene name='pdbligand=LM8:(5Z,8Z,11Z,13S,14Z)-13-METHYLICOSA-5,8,11,14-TETRAENOIC+ACID'>LM8</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rut OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rut RCSB], [http://www.ebi.ac.uk/pdbsum/4rut PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE]] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Prostaglandin-endoperoxide synthase]] | ||
| + | [[Category: Banerjee, S]] | ||
| + | [[Category: Kudalkar, S N]] | ||
[[Category: Makriyannis, A]] | [[Category: Makriyannis, A]] | ||
| - | [[Category: Nikas, S | + | [[Category: Marnett, L J]] |
| + | [[Category: Nikas, S P]] | ||
[[Category: Xu, S]] | [[Category: Xu, S]] | ||
| - | [[Category: | + | [[Category: Fatty acid analog]] |
| - | [[Category: | + | [[Category: Glycosylation]] |
| - | [[Category: | + | [[Category: Membrane]] |
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Protein-ligand complex]] | ||
Revision as of 11:59, 12 February 2015
crystal structure of murine cyclooxygenase-2 with 13-methyl-arachidonic Acid
| |||||||||||
